Browsing by Subject "Neurodegeneration"
Now showing items 1-18 of 18
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Comparing Pathways for Retinal and Neuronal Degeneration in Drosophila melanogaster
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2023)Past work to understand the mechanisms of cellular degeneration has either focused on retinal degeneration or neurodegeneration. These studies have revealed that the integrated stress response (ISR) and RNA binding proteins ... -
Development of an Objective Assessment of the Cognitive, Posturographic, and Electrophysiological Phenotype of the Fragile X Premutation, and analysis of their contribution to Postural Instability.
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2021)The Fragile X Premutation is a complex genetic anomaly which affects one in 260 females and 400 males and results in a broad range of symptoms and distinct conditions. The premutation phenotype involves cognitive and motor ... -
Epigenome-wide meta-analysis of blood DNA methylation and its association with subcortical volumes: findings from the ENIGMA Epigenetics Working Group
(2019)DNA methylation, which is modulated by both genetic factors and environmental exposures, may offer a unique opportunity to discover novel biomarkers of disease-related brain phenotypes, even when measured in other tissues ... -
Examining short interval intracortical inhibition with different transcranial magnetic stimulation-induced current directions in ALS
(2024)Objective: To establish if induced current direction across the motor cortex alters the sensitivity of transcranial magnetic stimulation (TMS)-evoked short-interval intracortical inhibition (SICI) as an ALS biomarker. Methods: ... -
Examining the Role of Ataxin-2 Protein and its Domains in Cellular Function, Translational Control and Neurodegeneration
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2023)Ataxin-2 (ATXN2) is a gene implicated in spinocerebellar ataxia type II (SCA2), amyotrophic lateral sclerosis (ALS) and Parkinsonism. The encoded protein is a therapeutic target for ALS and related conditions. ATXN2 (or ... -
Existing evidence for the repurposing of PARP-1 inhibitors in rare demyelinating diseases
(2022)Over the past decade, Poly (ADP-ribose) polymerase-1 (PARP-1) inhibitors have arisen as a novel and promising targeted therapy for breast cancer gene (BRCA)-mutated ovarian and breast cancer patients. Therapies targeting ... -
Extracellular forms of A� and tau from iPSC models of Alzheimer's disease disrupt synaptic plasticity
(2018)The early stages of Alzheimer’s disease are associated with synaptic dysfunction prior to overt loss of neurons. To identify extracellular molecules that impair synaptic plasticity in the brain, we studied the secretomes ... -
Genetic heterogeneity in amyotrophic lateral sclerosis and related disorders
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2022)The overarching aim of this thesis is to clarify and further our understanding of the genetic causes of amyotrophic lateral sclerosis (ALS) and related diseases. It is hoped that achieving this can help bring clarity to ... -
GluN2B subunit-containing NMDA receptor antagonists prevent Abeta-mediated synaptic plasticity disruption in vivo
(2009)Currently, treatment with the relatively low-affinity NMDA receptor antagonist memantine provides limited benefit in Alzheimer's disease (AD). One probable dose-limiting factor in the use of memantine is the inhibition of ... -
IL-33 deficiency causes persistent inflammation and severe neurodegeneration in retinal detachment
(2019)Background: Interleukin-33 (IL-33) belongs to the IL-1 cytokine family and resides in the nuclei of various cell types. In the neural retina, IL-33 is predominately expressed in Müller cells although its role in health ... -
Neurophysiological markers of network dysfunction in neurodegenerative diseases
(Elsevier, 2019)There is strong clinical, imaging and pathological evidence that neurodegeneration is associated with altered brain connectivity. While functional imaging (fMRI) can detect resting and activated states of metabolic activity, ... -
Partial inhibition of complex I activity increases Ca2+-independent glutamate release rates from synaptosomes
(2008)Mitochondria have been implicated in the pathogenesis of several neurodegenerative disorders and, in particular, complex I (NADH:ubiquinone oxidoreductase, EC 1.6.5.3) activity has been shown to be partially reduced in ... -
PATHOGENIC PROTEIN AGGREGATION IN VIVO AND IN VITRO
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2022)Neurodegenerative disorders (ND) such as Alzheimer?s disease (AD), Parkinson?s disease (PD) and amyotrophic lateral sclerosis (ALS) are one of the leading causes of death and disabilities worldwide. While their aetiologies ... -
Patient-derived tau and amyloid-beta facilitate long-term depression in vivo: role of tumor necrosis factor alpha and the integrated stress response
(2024)Alzheimer’s disease is characterized by progressive cognitive decline in older individuals accompanied by the deposition of two pathognomonic proteins amyloid β (Aβ) and tau. It is well documented that synaptotoxic soluble ... -
RNP Granules and Neurodegeneration: Molecular Strategies to Regulate Condensation and Aggregation
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2024)Eukaryotic cell organisation is classically described in terms of a cytoplasm and discrete, membrane-bound organelles enclosed within a plasma membrane. However, more recently it has been recognised that cells also organise ... -
The role of the Locus Coeruleus-Noradrenergic system integrity in the main Dementia modifiable risk factors: a comparative approach linking neuropsychological measures to biological and lifestyle indices
(Trinity College Dublin. School of Psychology. Discipline of Psychology, 2023)Dementia etiopathogenesis is characterised by a plethora of heterogeneous and diverse factors, which contribute to delay the definition of effective treatments and preventing strategies. Growing evidence identifies in the ... -
A Study of Mitochondrial Dynamics and Glycosylation Events in PC12 Cells and Neurons
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2017)Summary Mitochondrial dysfunction is recognised as a hallmark of many neurodegenerative diseases. Altered electron transport chain (ETC) complex activities, mitochondrial fusion/fission dynamics, mitochondrial motility ... -
Virtual brain biopsies in amyotrophic lateral sclerosis: diagnostic classification based on in vivo pathological patterns
(2017)Background: Diagnostic uncertainty in ALS has serious management implications and delays recruitment into clinical trials. Emerging evidence of presymptomatic disease-burden provides the rationale to develop diagnostic ...
