Browsing by Subject "Innate immunity"
Now showing items 1-20 of 20
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Altered endotoxin responsiveness in healthy children with Down syndrome.
(2018)Background: Down syndrome (DS) is the most common syndromic immunodeficiency with an increased risk of infection, mortality from sepsis, and autoinflammation. Innate immune function is altered in DS and therefore we examined ... -
Characterisation of innate immune responses in children with Down syndrome
(Trinity College Dublin. School of Medicine. Discipline of Paediatrics, 2020)Introduction: Down syndrome (DS) is associated with increased incidence of infections in childhood, higher mortality from sepsis, and other inflammatory conditions such as arthropathy, thyroid and coeliac disease. Several ... -
A Cross-Disease Study Investigating the Phenotypic and Functional Heterogeneity in Neutrophil Subsets
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2024)Neutrophils play a critical role in the innate immune response. They are the most abundant leukocytes in humans and are the first line of defence against invading microorganisms; growing evidence in the last decade has ... -
Detection of Viral Infections by Innate Immunity
(2021)Pattern recognition receptors (PRRs) and inflammasomes are a key part of the anti-viral innate immune system as they detect conserved viral pathogen-associated molecular patterns (PAMPs). A successful host response to viral ... -
Editorial: Tregs and BCG - Dangerous liaisons in TB
(2010)A discussion on paper by Ho et al. providing evidence to support the hypothesis that Treg cells induced by environmental mycobacteria do indeed constrain immunity induced by BCG. -
The emerging role of human PYHIN proteins in innate immunity: Implications for health and disease.
(2014)The innate immune response depends on the ability of immune cells to detect pathogens through germline-encoded pattern recognition receptors (PRRs). Recently discovered PRRs include some members of the Pyrin and HIN domain ... -
Fibronectin-binding protein B (FnBPB) from Staphylococcus aureus protects against the antimicrobial activity of histones
(2019)Staphylococcus aureus is a Gram-positive bacterium that can cause both superficial and deep-seated infections. Histones released by neutrophils kill bacteria by binding to the bacterial cell surface and causing membrane ... -
Guardians of the Cell: Effector-Triggered Immunity Steers Mammalian Immune Defense
(2019)The mammalian innate immune system deals with invading pathogens and stress by activating pattern-recognition receptors (PRRs) in the host. Initially proposed to be triggered by the discrimination of defined molecular ... -
Harnessing the innate and adaptive immune system for tissue repair and regeneration: Considering more than macrophages
(2021)Tissue healing and regeneration is a complex, choreographed, spatiotemporal process involving a plethora of cell types, the activity of which is stringently regulated in order for effective tissue repair to ensue post ... -
Immune Dysregulation in Children With Down Syndrome
(2020)Down syndrome (DS) is the most common genetic syndrome associated with immune defects. The extent of immune dysregulation in DS is substantial, spanning the innate and adaptive systems and including anomalies in: T and ... -
Increased systemic inflammation in children with Down syndrome
(2020)Children with Down syndrome (DS) develop more infections, have an increased mortality from sepsis and an increased incidence of chronic inflammatory conditions. Cytokine dysregulation may underpin these clinical sequelae ... -
Innate lymphoid cells and parasites: Ancient foes with shared history
(2018)This special issue of Parasite Immunology charts the rapid advances made in our understanding of the myriad interactions between innate lymphoid cells and parasites and how these interactions have shaped our evolutionary ... -
Investigating Molluscum Contagiosum Virus Protein MC008 and its Effect on Inflammatory Signalling
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2023)Molluscum contagiosum virus (MCV) is a human-adapted poxvirus that causes a common, persistent, yet mild infection characterized by distinct, contagious, papular skin lesions. These lesions are notable for having little ... -
Investigating the Signalling and Function of C5aR2
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2023)Complement component 5a receptor 2 (C5aR2) is an enigmatic receptor for anaphylatoxin C5a. It was initially thought to be a decoy receptor, competitively binding to C5a to negatively regulate C5aR1 signalling. However, ... -
Non-canonical Activation of the DNA Sensing Adaptor STING by ATM and IFI16 Mediates NF-κB Signaling after Nuclear DNA Damage.
(2018)DNA damage can be sensed as a danger-associated molecular pattern by the innate immune system. Here we find that keratinocytes and other human cells mount an innate immune response within hours of etoposide-induced DNA ... -
An overview of current knowledge of deadly covs and their interface with innate immunity
(2021)Coronaviruses are a large family of zoonotic RNA viruses, whose infection can lead to mild or lethal respiratory tract disease. Severe Acute Respiratory Syndrome-Coronavirus-1 (SARS-CoV-1) first emerged in Guangdong, China ... -
PYHIN protein IFI207 regulates cytokine transcription and IRF7 and contributes to the establishment of K. pneumoniae infection
(2023)PYHIN proteins AIM2 and IFI204 sense pathogen DNA, while other PYHINs have been shown to regulate host gene expression through as-yet unclear mechanisms. We characterize mouse PYHIN IFI207, which we find is not involved ... -
Role of the Elongator complex in innate immune responses of macrophages
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2023)The innate immune system functions as the first line of defence against pathogen infection. Innate immune systems are functionally present across the animal kingdom and mediate host defence against infection via a myriad ... -
T Helper 2 Cytokines Inhibit Autophagic Control of Intracellular Mycobacterium tuberculosis
(Elsevier, 2007)Autophagy is a recently recognized immune effect or mechanism against intracellular pathogens. The role of autophagy in innate immunity has been well established, but the extent of its regulation by the adaptive immune ... -
Toll-like receptor 2-dependent endosomal signaling by Staphylococcus aureus in monocytes induces type i interferon and promotes intracellular survival
(2019)Pathogen activation of innate immune pattern recognition receptors (PRRs) such as Toll-like receptors (TLRs) stimulates cellular signaling pathways. This often leads to outcomes that contribute to pathogen clearance. ...
