Browsing by Subject "Infection"
Now showing items 1-20 of 32
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Antimicrobial management and appropriateness of treatment of urinary tract infection in general practice in Ireland.
(2011)BACKGROUND: Urinary tract infections (UTIs) are the second most common bacterial infections in general practice and a frequent indication for prescription of antimicrobials. Increasing concern about the association between ... -
Autophagy and cytokines
(2011)Autophagy is a highly conserved homoeostatic mechanism for the lysosomal degradation of cytosolic constituents, including long-lived macromolecules, organelles and intracellular pathogens. Autophagosomes are formed in ... -
Autophagy controls IL-1? secretion by targeting pro-IL-1? for degradation
(2011)Autophagy is a key regulator of cellular homeostasis that can be activated by pathogen-associated molecules and recently has been shown to influence IL-1? secretion by macrophages. However, the mechanisms behind this are ... -
Bacterial L-forms on tap: an improved methodology to generate Bacillus subtilis L-forms heralds a new era of research
(2012)Bacterial L-forms are cell wall-less forms of bacteria that usually grow with a conventional cell wall. Despite being important for research, L-forms are difficult to generate reproducibly and research in this area is ... -
CD4 TRMcells following infection and immunization: Implications for more effective vaccine design
(2018)The induction of immunological memory, which is mediated by memory T and B cells, is central to adaptive protective immunity to pathogens induced by previous infection and is the cornerstone of effective vaccine design. ... -
Crystallization of an engineered RUN domain of Rab6-interacting protein 1/DENND5.
(International Union of Crystallography, 2011)Effectors of the Rab small GTPases are large multi-domain proteins which have proved difficult to express in soluble form in Escherichia coli. Generally, effectors are recruited to a distinct subcellular compartment by ... -
Distribution of SCCmec-associated phenol-soluble modulin in staphylococci
(2012)The recently described phenol-soluble modulin PSM-mec was detected in S. aureus, S. epidermidis, S. fleuretti, S. hominis, S. pseudintermedius, S. saprophyticus, S. simulans and S. vitulinus from different hosts (humans, ... -
Diverse Immunoregulatory Roles of Oxysterols - The Oxidized Cholesterol Metabolites
(2020)Intermediates of both cholesterol synthesis and cholesterol metabolism can have diverse roles in the control of cellular processes that go beyond the control of cholesterol homeostasis. For example, oxidized forms of ... -
DNA MICROARRAY GENOTYPING AND VIRULENCE AND ANTIMICROBIAL RESISTANCE GENE PROFILING OF METHICILLIN-RESISTANT Staphylococcus aureus BLOODSTREAM ISOLATES FROM RENAL PATIENTS
(2011)Thirty-six methicillin-resistant Staphylococcus aureus (MRSA) bloodstream isolates from renal patients were genetically characterized by DNA microarray analysis and spa typing. The isolates were highly clonal, belonging ... -
Environmental risk factors associated with ANCA associated vasculitis: A systematic mapping review.
(2020)Background: Anti-neutrophil cytoplasm antibody (ANCA)-associated vasculitis (AAV) is a rare multi-system autoimmune disease, characterised by a pauci-immune necrotising small-vessel vasculitis, with a relapsing and remitting ... -
Identification of the synthetic cannabinoid R(+)WIN55,212-2 as a novel regulator of IFN regulatory factor 3 (IRF3) activation and IFN-{beta} expression: relevance to therapeutic effects in models of multiple sclerosis.
(2011)?-Interferons (IFN-?s) represent one of the first line treatments for relapsing-remitting multiple sclerosis, slowing disease progression while reducing the frequency of relapses. Despite this, more effective, well tolerated ... -
Inflammasome activation: from inflammatory disease to infection
(2011)The recognition of pathogen-derived molecules by the innate immune system is mediated by a number of receptors, including members of the TLR (Toll-like receptor), RLH [RIG (retinoic acid-inducible gene)-like helicase] and ... -
Long-term potentiation is impaired in CD200-deficient mice: a role for Toll-like receptor activation.
(2011)The membrane glycoprotein CD200 is expressed on several cell types including neurons whereas expression of its receptor, CD200R, is restricted principally to cells of the myeloid lineage, including microglia. The interaction ... -
Lower filamentation rates of Candida dubliniensis contribute to its lower virulence in comparison with Candida albicans
(Elsevier, 2007)Candida albicans and Candida dubliniensis are very closely related yeast species. In this study, we have conducted a thorough comparison of the ability of the two species to produce hyphae and their virulence in two ... -
MicroRNAs and the resolution phase of in?ammation in macrophages
(John Wiley & Sons, Ltd., 2011)Toll-like receptors (TLRs) signal the presence of pathogens and tissue injury, triggering the inflammatory process in macrophages. The goal of inflammation is to resolve the injury and return the body to homeostasis. ... -
Mycobacterial PIMs Inhibit Host Inflammatory Responses through CD14-Dependent and CD14-Independent Mechanisms
(2011)Mycobacteria develop strategies to evade the host immune system. Among them, mycobacterial LAM or PIMs inhibit the expression of pro-inflammatory cytokines by activated macrophages. Here, using synthetic PIM analogues, we ... -
Non-Steroidal Anti-Inflammatory Drugs and Cognitive Function: Are Prostaglandins at the Heart of Cognitive Impairment in Dementia and Delirium ?
(2012)Studies of non-steroidal anti-inflammatory drugs (NSAIDs) in rheumatoid arthritis imply that inflammation is important in the development of Alzheimer's disease (AD). However, these drugs have not alleviated the symptoms ... -
The nucleoid-associated protein HU controls three regulons that coordinate virulence, response to stress and general physiology in Salmonella enterica serovar Typhimurium
(2011)The role of the HU nucleoid-associated proteins in gene regulation was examined in Salmonella enterica serovar Typhimurium. The dimeric HU protein consists of different combinations of its ? and ? subunits. Transcriptomic ... -
Omega-3 fatty acids attenuate dendritic cell function via NF-kappa B independent of PPAR gamma
(2011)Long-chain n-3 polyunsaturated fatty acids (n-3 PUFA) have been shown to modulate the immune response and have therapeutic effects in inflammatory disorders. PUFA are also peroxisome proliferators-activator receptor-gamma ... -
Phenotype and Function of CD25-Expressing B Lymphocytes Isolated from Human Umbilical Cord Blood
(2011)Background. We have shown that approximately 30% of human peripheral blood B-cells express CD25. B cells expressing CD25 display a mature phenotype belonging to the memory B-cell population and have a better proliferative ...
