Browsing by Subject "Down syndrome"
Now showing items 1-8 of 8
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Characterisation of innate immune responses in children with Down syndrome
(Trinity College Dublin. School of Medicine. Discipline of Paediatrics, 2020)Introduction: Down syndrome (DS) is associated with increased incidence of infections in childhood, higher mortality from sepsis, and other inflammatory conditions such as arthropathy, thyroid and coeliac disease. Several ... -
Cognitive reserve and dementia risk management in people with an intellectual disability.
(2023)Dementia risk is elevated in people with intellectual disability, particularly for those with Down syndrome Differences in lifestyle factors have been cited as factors that exacerbate dementia risk in people with ... -
Examining the effects of cognitive training on levels of executive function in adults with down syndrome: A feasibility study
(Trinity College Dublin. School of Nursing & Midwifery. Discipline of Nursing, 2017)Introduction Individuals with Down syndrome are at much greater risk of developing AD, and one of the early clinical symptoms of AD is executive dysfunction. In the general population, cognitive training has shown some ... -
Extracellular forms of A� and tau from iPSC models of Alzheimer's disease disrupt synaptic plasticity
(2018)The early stages of Alzheimer’s disease are associated with synaptic dysfunction prior to overt loss of neurons. To identify extracellular molecules that impair synaptic plasticity in the brain, we studied the secretomes ... -
Immune Dysregulation in Children With Down Syndrome
(2020)Down syndrome (DS) is the most common genetic syndrome associated with immune defects. The extent of immune dysregulation in DS is substantial, spanning the innate and adaptive systems and including anomalies in: T and ... -
Increased systemic inflammation in children with Down syndrome
(2020)Children with Down syndrome (DS) develop more infections, have an increased mortality from sepsis and an increased incidence of chronic inflammatory conditions. Cytokine dysregulation may underpin these clinical sequelae ... -
A Longitudinal Examination of the Physical Health and Ageing of Individuals with Down syndrome in Ireland
Background: Over the past three decades the life expectancy of people with Down syndrome (DS) has dramatically increased with improvements in health service delivery, better knowledge, health care and advocacy. With increased ... -
Ten-year survival of Down syndrome births.
(1997)Objective: To determine the survival status of children with Down syndrome (DS), and to document factors influencing survival. Design: Follow-up study of cases identified from the Dublin European Register of Congenital ...
