Browsing by Subject "Ageing, memory and other cognitive processes"
Now showing items 1-4 of 4
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Extracellular forms of A� and tau from iPSC models of Alzheimer's disease disrupt synaptic plasticity
(2018)The early stages of Alzheimer’s disease are associated with synaptic dysfunction prior to overt loss of neurons. To identify extracellular molecules that impair synaptic plasticity in the brain, we studied the secretomes ... -
GluN2B subunit-containing NMDA receptor antagonists prevent Abeta-mediated synaptic plasticity disruption in vivo
(2009)Currently, treatment with the relatively low-affinity NMDA receptor antagonist memantine provides limited benefit in Alzheimer's disease (AD). One probable dose-limiting factor in the use of memantine is the inhibition of ... -
Patient-derived tau and amyloid-beta facilitate long-term depression in vivo: role of tumor necrosis factor alpha and the integrated stress response
(2024)Alzheimer’s disease is characterized by progressive cognitive decline in older individuals accompanied by the deposition of two pathognomonic proteins amyloid β (Aβ) and tau. It is well documented that synaptotoxic soluble ... -
Young and Restless, Old and Focused: Age-Differences in Mind-Wandering Frequency and Phenomenology
(2020)The consistently observed age-accompanied diminution in mind-wandering stands seemingly opposed to accounts that present mind-wandering as a failure of executive control. This study examined the impact of aging on the ...
