Browsing by Subject "Age related diseases"
Now showing items 1-20 of 40
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α-TLR2 antibody attenuates the Aβ-mediated inflammatory response in microglia through enhanced expression of SIGIRR.
(2015)The immunoregulatory function of single-Ig-interleukin-1 related receptor (SIGIRR) is derived from its ability to constrain the inflammatory consequences of interleukin (IL)-1R and toll-like receptor (TLR)4 activation. ... -
Ageism in Stroke Rehabilitation Studies
(2014)Background: stroke is predominantly a disease of older people. While age bias has been demonstrated in studies of pharmacological therapeutic interventions in stroke, the extent of discrimination by age in stroke rehabilitation ... -
Aging impairs peritoneal but not bone marrow-derived macrophage phagocytosis.
(2014)Aging results in deterioration of the immune system, which is associated with increased susceptibility to infection and impaired wound healing in the elderly. Phagocytosis is an essential process in both wound healing and ... -
Analysis of amyotrophic lateral sclerosis as a multistep process: a population-based modelling study
(2014)Background Amyotrophic lateral sclerosis shares characteristics with some cancers, such as onset being more common in later life, progression usually being rapid, the disease affecting a particular cell type, and showing ... -
Bone Marrow-Derived Macrophages from AβPP/PS1 Mice are Sensitized to the Effects of Inflammatory Stimuli.
(2015)Macrophages are key cells in tissue defense in the periphery and, under certain circumstances, infiltrate the central nervous system, where they may play a similar role in the brain, perhaps supporting the function of ... -
Cardiovascular Control during Exercise in Type 2 Diabetes Mellitus
(2015)Controlled studies of male and female subjects with type 2 diabetes mellitus (DM) of short duration (~3–5 years) show that DM reduces peak (L·min−1 and mL·kg−1·min−1) by an average of 12–15% and induces a greater slowing ... -
Characteristics and outcomes of older persons attending the emergency department: a retrospective cohort study.
(2014)Background: The analysis of routinely collected hospital data informs the design of specialist services for at-risk older people. Aim: Describe the outcomes of a cohort of older emergency department (ED) attendees and ... -
Examining short interval intracortical inhibition with different transcranial magnetic stimulation-induced current directions in ALS
(2024)Objective: To establish if induced current direction across the motor cortex alters the sensitivity of transcranial magnetic stimulation (TMS)-evoked short-interval intracortical inhibition (SICI) as an ALS biomarker. Methods: ... -
An Exploratory Spatial Analysis of ALS Incidence in Ireland over 17.5 Years (1995 - July 2013)
(2014)Abstract Introduction There has been much interest in spatial analysis of ALS to identify potential environmental or genetically caused clusters of disease. Results to date have been inconclusive. The Irish ALS register ... -
Extracellular forms of A� and tau from iPSC models of Alzheimer's disease disrupt synaptic plasticity
(2018)The early stages of Alzheimer’s disease are associated with synaptic dysfunction prior to overt loss of neurons. To identify extracellular molecules that impair synaptic plasticity in the brain, we studied the secretomes ... -
GluN2B subunit-containing NMDA receptor antagonists prevent Abeta-mediated synaptic plasticity disruption in vivo
(2009)Currently, treatment with the relatively low-affinity NMDA receptor antagonist memantine provides limited benefit in Alzheimer's disease (AD). One probable dose-limiting factor in the use of memantine is the inhibition of ... -
Improving the efficiency of multisensory integration in older adults: audio-visual temporal discrimination training reduces the susceptibility to the sound-induced flash illusion.
(2014)From language to motor control, efficient integration of information from different sensory modalities is necessary for maintaining a coherent interaction with the environment. While a number of training studies have focused ...
