Browsing by Author "SULLIVAN, DEREK"
Now showing items 1-20 of 21
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AVIAN-ASSOCIATED AND HUMAN ISOLATES OF Candida dubliniensis ARE GENETICALLY DISTINCT
(2009)When Candida dubliniensis isolates obtained from seabird excrement and from humans in Ireland were compared by using multilocs sequence typing, 13 of 14 avian isolates were genetically distinct from human isolates. The ... -
CANDIDA ALBICANS VERSUS CANDIDA DUBLINIENSIS: WHY IS C. ALBICANS MORE PATHOGENIC?
(2012)Candida albicans and Candida dubliniensis are highly related pathogenic yeast species. However, C. albicans is far more prevalent in human infection and has been shown to be more pathogenic in a wide range of infection ... -
Candida dubliniensis: An update
(1999)The increased incidence of fungal infections during the last decade has been well-documented. Given that one of the most important factors contributing to this phenomenon is the increased numbers of immunocompromised ... -
COMPARATIVE ADHERENCE OF CANDIDA ALBICANS AND CANDIDA DUBLINIENSIS TO HUMAN BUCCAL EPITHELIAL CELLS AND EXTRACELLULAR MATRIX PROTEINS
(2014)Candida albicans and Candida dubliniensis are very closely related pathogenic yeast species. Despite their close relationship, the former is a far more successful coloniser and pathogen of humans. The purpose of the current ... -
COMPARATIVE GENOMICS AND THE EVOLUTION OF PATHOGENICITY IN HUMAN PATHOGENIC FUNGI
(2011)Because most fungi have evolved to be free-living in the environment and because the infections they cause are usually opportunistic in nature, it is often difficult to identify specific traits that contribute to fungal ... -
COMPARATIVE GENOMICS USING CANDIDA ALBICANS DNA MICROARRAYS REVEALS ABSENCE AND DIVERGENCE OF VIRULENCE ASSOCIATED GENES IN CANDIDA DUBLINIENSIS
(2004)Candida dubliniensis is a pathogenic yeast species closely related to Candida albicans. However, it is less frequently associated with human disease and displays reduced virulence in animal models of infection. We have ... -
DIFFERENTIAL REGULATION OF THE TRANSCRIPTIONAL REPRESSOR NRG1 ACCOUNTS FOR ALTERED HOST CELL INTERACTIONS IN CANDIDA ALBICANS AND CANDIDA DUBLINIENSIS
(2007)Candida dubliniensis is genetically closely related to C. albicans, but causes fewer infections in humans and exhibits reduced virulence and filamentation in animal models of infection. We investigated the role of the ... -
DIFFERENTIAL REGULATION OF THE TRANSCRIPTIONAL REPRESSOR NRG1 ACCOUNTS FOR ALTERED HOST CELL INTERACTIONS IN CANDIDA ALBICANS AND CANDIDA DUBLINIENSIS
(Blackwell Publishing, 2007-09)Candida dubliniensis is genetically closely related to C. albicans, but causes fewer infections in humans and exhibits reduced virulence and filamentation in animal models of infection. We investigated the role of the C. ... -
Emergence of Sequence Type 779 Methicillin-Resistant Staphylococcus aureus (MRSA) Harboring a Novel Pseudo Staphylococcal Cassette Chromosome mec (SCCmec)-SCC-SCCCRISPR Composite Element in Irish Hospitals.
(2013)Methicillin-resistant Staphylococcus aureus (MRSA) has been a major cause of nosocomial infection in Irish hospitals for 4 decades, and replacement of predominant MRSA clones has occurred several times. An MRSA isolate ... -
EXTENSIVE GENETIC DIVERSITY IDENTIFIED AMONG SPORADIC METHICILLIN-RESISTANT Staphylococcus aureus ISOLATES RECOVERED IN IRISH HOSPITALS BETWEEN 2000-2012
(2014)Clonal replacement of predominant nosocomial methicillin-resistant Staphylococcus aureus (MRSA) strains has occurred several times in Ireland during the last four decades. However, little is known about sporadically-occurring ... -
Genome-wide gene expression profiling and a forward genetic screen show that differential expression of the sodium ion transporter Ena21 contributes to the differential tolerance of Candida albicans and Candida dubliniensis to osmotic stress
(Wiley-Blackwell, 2009)Candida albicans is more pathogenic than Candida dubliniensis. However, this disparity in virulence is surprising given the high level of sequence conservation and the wide range of phenotypic traits shared by these two ... -
Global Transcriptome Sequencing Identifies Chlamydospore Specific Markers in Candida albicans and Candida dubliniensis.
(2013)Candida albicans and Candida dubliniensis are pathogenic fungi that are highly related but differ in virulence and in some phenotypic traits. During in vitro growth on certain nutrient-poor media, C. albicans and C. ... -
Lower filamentation rates of Candida dubliniensis contribute to its lower virulence in comparison with Candida albicans
(Elsevier, 2007)Candida albicans and Candida dubliniensis are very closely related yeast species. In this study, we have conducted a thorough comparison of the ability of the two species to produce hyphae and their virulence in two ... -
MICROBIOLOGICAL SCREENING OF IRISH AUTOIMMUNE POLYENDOCRINOPATHY-CANDIDIASIS-ECTODERMAL DYSTROPHY (APECED) PATIENTS REVEALS PERSISTENCE OF CANDIDA ALBICANS STRAINS, GRADUAL REDUCTION IN SUSCEPTIBILITY TO AZOLES AND INCIDENCES OF CLINICAL SIGNS OF ORAL CANDIDIASIS WITHOUT CULTURE EVIDENCE
(2011)Patients with Autoimmune Polyendocrinopathy Candidiasis Ectodermal Dystrophy (APECED) are prone to chronic mucocutaneous candidiasis, which is often treated with azoles. The purpose of this study was to characterize the ... -
MULTILOCUS SEQUENCE TYPING REVEALS THAT THE POPULATION STRUCTURE OF Candida dubliniensis IS SIGNIFICANTLY LESS DIVERGENT THAN THAT OF Candida albicans
(2008)he pathogenic yeast Candida dubliniensis is phylogenetically very closely related to Candida albicans, and both species share many phenotypic and genetic characteristics. DNA fingerprinting using the species-specific probe ... -
NOVEL 5-FLUCYTOSINE-RESISTANT CLADE OF CANDIDA DUBLINIENSIS FROM SAUDI ARABIA AND EGYPT IDENTIFIED BY CD25 FINGERPRINTING.
(2005)DNA fingerprinting of Candida dubliniensis isolates using the species-specific probe Cd25 previously showed that this species consists of two distinct groups, termed Cd25 group I and Cd25 group II. The present study ... -
Purification and germination of Candida albicans and Candida dubliniensis chlamydospores cultured in liquid media
(2009-06-30)Candida albicans and Candida dubliniensis are the only Candida species that have been observed to produce chlamydospores. The function of these large, thick-walled cells is currently unknown. In this report we describe ... -
Reduced azole susceptibility in genotype 3 C. dubliniensis isolates associated with increased CdCDR1 and CdCDR2 expression.
(2005)Candida dubliniensis is a recently identified yeast species primarily associated with oral carriage and infection in HIV-infected individuals. The species can be divided into at least four genotypes on the basis of the ... -
A Ser29Leu SUBSTITUTION IN THE CYTOSINE DEAMINASE Fca1p IS RESPONSIBLE FOR CLADE-SPECIFIC 5-FLUCYTOSINE RESISTANCE IN Candida dubliniensis
(2009)The population structure of the opportunistic yeast pathogen Candida dubliniensis is composed of three main multilocus sequence typing clades (clades C1 to C3), and clade C3 predominantly consists of isolates from the ... -
Telomeric ORFs (TLOs) in Candida spp. encode Mediator subunits that regulate distinct virulence traits
(2014)The TLO genes are a family of telomere-associated ORFs in the fungal pathogens Candida albicans and C. dubliniensis that encode a subunit of the Mediator complex with homology to Med2. The more virulent pathogen C. albicans ...
