Browsing by Author "Rowan, Michael"
Now showing items 1-8 of 8
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Alzheimer's disease A� assemblies mediating rapid disruption of synaptic plasticity and memory.
(2012)Alzheimer’s disease (AD) is characterized by episodic memory impairment that often precedes clinical diagnosis by many years. Probing the mechanisms of such impairment may provide much needed means of diagnosis and therapeutic ... -
Aß Facilitates LTD at Schaffer Collateral Synapses Preferentially in the Left Hippocampus
(2018)Promotion of long-term depression (LTD) mechanisms by synaptotoxic soluble oligomers of amyloid-β (Aß) has been proposed to underlie synaptic dysfunction in Alzheimer’s disease (AD). Previously, LTD was induced by relatively ... -
Extracellular forms of A� and tau from iPSC models of Alzheimer's disease disrupt synaptic plasticity
(2018)The early stages of Alzheimer’s disease are associated with synaptic dysfunction prior to overt loss of neurons. To identify extracellular molecules that impair synaptic plasticity in the brain, we studied the secretomes ... -
GluN2B subunit-containing NMDA receptor antagonists prevent Abeta-mediated synaptic plasticity disruption in vivo
(2009)Currently, treatment with the relatively low-affinity NMDA receptor antagonist memantine provides limited benefit in Alzheimer's disease (AD). One probable dose-limiting factor in the use of memantine is the inhibition of ... -
Glutamate receptors in preclinical research on Alzheimer's disease: update on recent advances
(2012)The cognitive and related symptoms of Alzheimer's disease are mainly attributable to synaptic failure. Here we review recent research on how the Alzheimer's disease amyloid ?-protein (A?) affects glutamate receptors and ... -
Patient-derived tau and amyloid-beta facilitate long-term depression in vivo: role of tumor necrosis factor alpha and the integrated stress response
(2024)Alzheimer’s disease is characterized by progressive cognitive decline in older individuals accompanied by the deposition of two pathognomonic proteins amyloid β (Aβ) and tau. It is well documented that synaptotoxic soluble ... -
Physiological activation of mGlu5 receptors supports the ion channel function of NMDA receptors in hippocampal LTD induction in vivo
(2018)Synaptic long-term depression (LTD) is believed to underlie critical mnemonic processes in the adult hippocampus. The roles of the metabotropic and ionotropic actions of glutamate in the induction of synaptic LTD by ... -
Switching off LTP: mGlu and NMDA receptor-dependent novelty exploration-induced depotentiation in the rat hippocampus.
(2013)Both electrically induced synaptic long-term potentiation (LTP) and long-term depression have been extensively studied as models of the cellular basis of learning and memory mechanisms. Recently, considerable interest has ...
