Browsing by Author "Knight, Silvin"
Now showing items 1-20 of 33
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Age-related normative changes in cerebral perfusion: data from The Irish Longitudinal Study on Ageing (TILDA)
(2021)Objective: To establish normative reference values for total grey matter cerebral blood flow (CBFGM) measured using pseudo-continuous arterial spin labelling (pCASL) MRI in a large cohort of community-dwelling adults aged ... -
Alluvial visualization and computation of probabilities of transitions in frailty index states over an 8-year period using multi-state Markov models
(2021)The Frailty Index (FI) is an operationalization of frailty in older adults based on the accumulation of health deficits. FI cut-offs define the non-frail, prefrail and frail states. We described longitudinal transitions ... -
Approximate entropies of resting state continuous neurocardiovascular physiological signals are associated with physical frailty in older adults
(2021)Frailty in older adults is characterised by dysregulation in multiple physiological systems. The frailty phenotype is defined on the basis of exhaustion, unexplained weight loss, weakness, slowness and low physical activity ... -
Associations between Cardiovascular Signal Entropy and Cognitive Performance over Eight Years
(2021)In this study, the relationship between non-invasively measured cardiovascular signal entropy and global cognitive performance was explored in a sample of community-dwelling older adults from The Irish Longitudinal Study ... -
Associations between neurocardiovascular signal entropy and physical frailty
(2021)In this cross-sectional study, the relationship between noninvasively measured neurocardiovascular signal entropy and physical frailty was explored in a sample of community-dwelling older adults from The Irish Longitudinal ... -
Blood Pressure Signal Entropy as a Novel Marker of Physical Frailty: Results from the FRAILMatics Clinical Cohort
(2022)In this study we investigated the association between information entropy in short length blood pressure signals and physical frailty status, in a group of patients aged 50+ recruited from the Falls and Syncope Unit at ... -
Brain-predicted age difference score is related to specific cognitive functions: a multi-site replication analysis
(2020)Brain-predicted age difference scores are calculated by subtracting chronological age from ‘brain’ age, which is estimated using neuroimaging data. Positive scores reflect accelerated ageing and are associated with increased ... -
Cardiovascular signal entropy predicts all-cause mortality: evidence from The Irish Longitudinal Study on Ageing (TILDA)
(2022)In this study, the relationship between cardiovascular signal entropy and the risk of seven-year all-cause mortality was explored in a large sample of community-dwelling older adults from The Irish Longitudinal Study on ... -
Comparative analysis of frailty identification criteria on continuous non-invasive neurocardiovascular signals during an active stand test in The Irish Longitudinal Study on Ageing (TILDA)
(2023)Frailty is a distinctive health state related to acceleration of biological ageing in which multiple body systems disproportionately lose their in-built reserves. Older people living with frailty are at higher risk of ... -
Comparison of gait speed reserve, usual gait speed, and maximum gait speed of adults aged 50+ in Ireland using explainable machine learning
(2021)Gait speed is a measure of general fitness. Changing from usual (UGS) to maximum (MGS) gait speed requires coordinated action of many body systems. Gait speed reserve (GSR) is defined as MGS–UGS. From a shortlist of 88 ... -
Deep Learning Retinal Image Analysis for the Detection of CKD and Cardiovascular Risk Factors in the General Population
(2022)Background: Retinal blood vessel patterns provide an opportunity to personalize an individuals risk assessment for CKD and cardiovascular risk factors (CVRF). In this study we propose a deep learning (DL) based prediction ... -
Differential Associations Between Two Markers of Probable Sarcopenia and Continuous Orthostatic Hemodynamics in The Irish Longitudinal Study on Ageing
(2022)Background: Sarcopenia and orthostatic hypotension are growing age-related health burdens associated with adverse outcomes including falls. Despite a possible pathophysiological link, the association between the two disorders ... -
Eight orthostatic haemodynamic patterns in The Irish Longitudinal Study on Ageing (TILDA): stability and clinical associations after 4 years
(2021)Previous research cross-sectionally characterised eight morphological systolic blood pres-sure (SBP) active stand (AS) patterns using a clinical clustering approach at Wave 1 (W1) of the IrishLongitudinal Study on Ageing. ... -
Evaluation of a 3-Item Health Index in Predicting Mortality Risk: A 12-Year Follow-Up Study
(2023)This study was carried out using a large cohort (N = 4265; 416 deceased) of older, community-dwelling adults from The Irish Longitudinal Study on Ageing (TILDA). The study compared the performance of a new 3-item health ... -
Functional Analysis of Continuous, High-Resolution Measures in Ageing Research: A Demonstration using Cerebral Oxygenation Data from The Irish Longitudinal Study on Ageing
(2020)Background: A shift towards the dynamic measurement of physiologic resilience and improved technology incorporated into experimental paradigms in aging research is producing high-resolution data. Identifying ... -
Functional clustering of continuous cardiovascular and brain oxygenation signals during an active stand test in The Irish Longitudinal Study on Ageing (TILDA)
(2023)In this study, we performed K-shape functional clustering of two non-invasive continuous cardiovascular (systolic Blood Pressure: sBP) and brain oxygenation (left frontal lobe Tissue Saturation Index: TSI) times series ... -
Grey matter volume in the right Angular Gyrus is associated with differential patterns of multisensory integration with ageing
(Elsevier BV, 2020)Multisensory perception might provide an important marker of brain function in ageing. However, the cortical structures supporting multisensory perception in ageing are poorly understood. In this study, we compared regional ... -
Haemodynamic Parameters Underlying the Relationship Between Sarcopenia and Blood Pressure Recovery on Standing
(2023)Background: Sarcopenia, delayed blood pressure (BP) recovery following standing, and orthostatic hypotension (OH) pose significant clinical challenges associated with ageing. While prior studies have established a link ... -
Hemodynamic and structural brain measures in high and low sedentary older adults
(2021)Due to its cardiovascular effects sedentary behaviour might impact cerebrovascular function in the long term, affecting cerebrovascular regulatory mechanisms and perfusion levels. Consequently this could underly potential ...
