Now showing items 1-2 of 2

    • Evaluation of the anti-cancer effects of a novel guanidinium-based compound, VP79s, in multiple myeloma 

      Amet, Rebecca (Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2020)
      Multiple myeloma (MM) is an incurable haematological malignancy accounting for 300-350 cancer diagnoses in Ireland each year. Mainly a disease of the elderly, MM is most prevalent in Western societies where aging populations ...
    • Structure-activity relationships, biological evaluation and structural studies of novel pyrrolonaphthoxazepines as antitumor agents 

      Zisterer, Daniela; O'Sullivan, Jeffrey; Brindisi, Margherita; Ulivieri, Cristina; Alfano, Gloria; Gemma, Sandra; de Asís Balaguer, Francisco; Khan, Tuhina; Grillo, Alessandro; Chemi, Giulia; Menchon, Grégory; Prota, Andrea E.; Olieric, Natacha; Lucena-Agell, Daniel; Barasoain, Isabel; Fernando Diaz, J.; Nebbioso, Angela; Conte, Mariarosaria; Lopresti, Ludovica; Magnano, Stefania; Amet, Rebecca; Kinsella, Paula; Ibrahim, Ola; Morbidelli, Lucia; Spaccapelo, Roberta; Baldari, Cosima; Butini, Stefania; Novellino, Ettore; Campiani, Giuseppe; Altucci, Lucia; Steinmetz, Michel O.; Brogi, Simone (2019)
      Microtubule-targeting agents (MTAs) are a class of clinically successful anti-cancer drugs. The emergence of multidrug resistance to MTAs imposes the need for developing new MTAs endowed with diverse mechanistic properties. ...