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dc.contributor.authorCampbell, Matthewen
dc.contributor.authorHudson, Natalieen
dc.date.accessioned2022-03-07T16:21:38Z
dc.date.available2022-03-07T16:21:38Z
dc.date.issued2021en
dc.date.submitted2021en
dc.identifier.citationHudson, Natalie and Campbell, Matthew, Tight Junctions of the Neurovascular Unit, Frontiers in molecular neuroscience, 14, 2021, 752781en
dc.identifier.issn1662-5099en
dc.identifier.otherYen
dc.identifier.urihttp://hdl.handle.net/2262/98260
dc.descriptionPUBLISHEDen
dc.description.abstractThe homeostatic balance of the brain and retina is maintained by the presence of the blood-brain and inner blood-retinal barrier (BBB/iBRB, respectively) which are highly specialized barriers. Endothelial cells forming the lining of these blood vessels are interconnected by the presence of tight junctions which form the BBB and iBRB. These tight junctions, formed of numerous interacting proteins, enable the entry of molecules into neural tissues while restricting the entry of harmful material such as anaphylatoxins, bacteria and viruses. If the tight junction complex becomes dysregulated due to changes in expression levels of one or more of the components, this can have detrimental effects leading to brain and retinal pathologyen
dc.format.extent752781en
dc.language.isoenen
dc.relation.ispartofseriesFrontiers in molecular neuroscienceen
dc.relation.ispartofseries14en
dc.rightsYen
dc.subjectBlood brain barrieren
dc.subjectEndothelial cellsen
dc.subjectInner blood-retinal barrieren
dc.subjectNeurovasculatureen
dc.subjectTight junctionen
dc.titleTight Junctions of the Neurovascular Uniten
dc.typeJournal Articleen
dc.type.supercollectionscholarly_publicationsen
dc.type.supercollectionrefereed_publicationsen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/campbem2en
dc.identifier.peoplefinderurlhttp://people.tcd.ie/hudsonnaen
dc.identifier.rssinternalid235884en
dc.identifier.doihttp://dx.doi.org/10.3389/fnmol.2021.752781en
dc.rights.ecaccessrightsopenAccess


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