Tight Junctions of the Neurovascular Unit
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Journal ArticleDate:
2021Access:
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Hudson, Natalie and Campbell, Matthew, Tight Junctions of the Neurovascular Unit, Frontiers in molecular neuroscience, 14, 2021, 752781Download Item:
Abstract:
The homeostatic balance of the brain and retina is maintained by the presence of the blood-brain and inner blood-retinal barrier (BBB/iBRB, respectively) which are highly specialized barriers. Endothelial cells forming the lining of these blood vessels are interconnected by the presence of tight junctions which form the BBB and iBRB. These tight junctions, formed of numerous interacting proteins, enable the entry of molecules into neural tissues while restricting the entry of harmful material such as anaphylatoxins, bacteria and viruses. If the tight junction complex becomes dysregulated due to changes in expression levels of one or more of the components, this can have detrimental effects leading to brain and retinal pathology
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http://people.tcd.ie/campbem2http://people.tcd.ie/hudsonna
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Author: Campbell, Matthew; Hudson, Natalie
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Frontiers in molecular neuroscience14
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Blood brain barrier, Endothelial cells, Inner blood-retinal barrier, Neurovasculature, Tight junctionDOI:
http://dx.doi.org/10.3389/fnmol.2021.752781ISSN:
1662-5099Metadata
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