Consortium neuroscience of attention deficit/hyperactivity disorder and autism spectrum disorder: The ENIGMA adventure
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2020Access:
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Hoogman, M. and van Rooij, D. and Klein, M. and Boedhoe, P. and Ilioska, I. and Li, T. and Patel, Y. and Postema, M.C. and Zhang-James, Y. and Anagnostou, E. and Arango, C. and Auzias, G. and Banaschewski, T. and Bau, C.H.D. and Behrmann, M. and Bellgrove, M.A. and Brandeis, D. and Brem, S. and Busatto, G.F. and Calderoni, S. and Calvo, R. and Castellanos, F.X. and Coghill, D. and Conzelmann, A. and Daly, E. and Deruelle, C. and Dinstein, I. and Durston, S. and Ecker, C. and Ehrlich, S. and Epstein, J.N. and Fair, D.A. and Fitzgerald, J. and Freitag, C.M. and Frodl, T. and Gallagher, L. and Grevet, E.H. and Haavik, J. and Hoekstra, P.J. and Janssen, J. and Karkashadze, G. and King, J.A. and Konrad, K. and Kuntsi, J. and Lazaro, L. and Lerch, J.P. and Lesch, K.-P. and Louza, M.R. and Luna, B. and Mattos, P. and McGrath, J. and Muratori, F. and Murphy, C. and Nigg, J.T. and Oberwelland-Weiss, E. and O'Gorman Tuura, R.L. and O'Hearn, K. and Oosterlaan, J. and Parellada, M. and Pauli, P. and Plessen, K.J. and Ramos-Quiroga, J.A. and Reif, A. and Reneman, L. and Retico, A. and Rosa, P.G.P. and Rubia, K. and Shaw, P. and Silk, T.J. and Tamm, L. and Vilarroya, O. and Walitza, S. and Jahanshad, N. and Faraone, S.V. and Francks, C. and van den Heuvel, O.A. and Paus, T. and Thompson, P.M. and Buitelaar, J.K. and Franke, B., Consortium neuroscience of attention deficit/hyperactivity disorder and autism spectrum disorder: The ENIGMA adventure, Human Brain Mapping, 2020Download Item:
Abstract:
Neuroimaging has been extensively used to study brain structure and function in individuals with attention deficit/hyperactivity disorder (ADHD) and autism spectrum disorder (ASD) over the past decades. Two of the main shortcomings of the neuroimaging literature of these disorders are the small sample sizes employed and the heterogeneity of methods used. In 2013 and 2014, the ENIGMA‐ADHD and ENIGMA‐ASD working groups were respectively, founded with a common goal to address these limitations. Here, we provide a narrative review of the thus far completed and still ongoing projects of these working groups. Due to an implicitly hierarchical psychiatric diagnostic classification system, the fields of ADHD and ASD have developed largely in isolation, despite the considerable overlap in the occurrence of the disorders. The collaboration between the ENIGMA‐ADHD and ‐ASD working groups seeks to bring the neuroimaging efforts of the two disorders closer together. The outcomes of case–control studies of subcortical and cortical structures showed that subcortical volumes are similarly affected in ASD and ADHD, albeit with small effect sizes. Cortical analyses identified unique differences in each disorder, but also considerable overlap between the two, specifically in cortical thickness. Ongoing work is examining alternative research questions, such as brain laterality, prediction of case–control status, and anatomical heterogeneity. In brief, great strides have been made toward fulfilling the aims of the ENIGMA collaborations, while new ideas and follow‐up analyses continue that include more imaging modalities (diffusion MRI and resting‐state functional MRI), collaborations with other large databases, and samples with dual diagnoses.
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http://people.tcd.ie/lgallaghhttp://people.tcd.ie/sandersj
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PUBLISHEDcited By 5
Author: Gallagher, Louise; Mc Grath, Jane
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dual diagnoses, attention deficit/hyperactivity disorder (ADHD), autism spectrum disorder (ASD), Subcortical volumes, NeuroimagingDOI:
http://dx.doi.org/10.1002/hbm.25029Metadata
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