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dc.contributor.authorSenge, Mathias
dc.date.accessioned2021-02-23T19:45:31Z
dc.date.available2021-02-23T19:45:31Z
dc.date.issued2020
dc.date.submitted2020en
dc.identifier.citationGierlich, P., Mata, A.I., Donohoe, C., Brito, R.M.M., Senge, M.O., Gomes-da-Silva, L.C., Ligand-Targeted Delivery of Photosensitizers for Cancer Treatment, Molecules, 2020 Nov 14;25(22):5317en
dc.identifier.otherY
dc.identifier.urihttp://hdl.handle.net/2262/95322
dc.description.abstractPhotodynamic therapy (PDT) is a promising cancer treatment which involves a photosensitizer (PS), light at a specific wavelength for PS activation and oxygen, which combine to elicit cell death. While the illumination required to activate a PS imparts a certain amount of selectivity to PDT treatments, poor tumor accumulation and cell internalization are still inherent properties of most intravenously administered PSs. As a result, common consequences of PDT include skin photosensitivity. To overcome the mentioned issues, PSs may be tailored to specifically target overexpressed biomarkers of tumors. This active targeting can be achieved by direct conjugation of the PS to a ligand with enhanced affinity for a target overexpressed on cancer cells and/or other cells of the tumor microenvironment. Alternatively, PSs may be incorporated into ligand-targeted nanocarriers, which may also encompass multi-functionalities, including diagnosis and therapy. In this review, we highlight the major advances in active targeting of PSs, either by means of ligand-derived bioconjugates or by exploiting ligand-targeting nanocarriers.en
dc.language.isoenen
dc.relation.ispartofseriesMolecules (Basel, Switzerland);
dc.relation.ispartofseries25;
dc.relation.ispartofseries22;
dc.rightsYen
dc.subjectActive targetingen
dc.subjectCanceren
dc.subjectDrug deliveryen
dc.subjectNanocarriersen
dc.subjectPhotodynamic therapyen
dc.titleLigand-Targeted Delivery of Photosensitizers for Cancer Treatmenten
dc.typeJournal Articleen
dc.type.supercollectionscholarly_publicationsen
dc.type.supercollectionrefereed_publicationsen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/sengem
dc.identifier.rssinternalid224210
dc.identifier.doihttp://dx.doi.org/10.3390/molecules25225317
dc.rights.ecaccessrightsopenAccess
dc.contributor.sponsorScience Foundation Irelanden
dc.contributor.sponsorGrantNumberIvP 13/IA/1894en


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