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dc.contributor.authorKnight, Silvin
dc.contributor.authorMc Crory, Cathal
dc.contributor.authorKenny, Rose
dc.contributor.authorWilliamson, Wilby
dc.date.accessioned2021-01-14T18:40:40Z
dc.date.available2021-01-14T18:40:40Z
dc.date.issued2020
dc.date.submitted2020en
dc.identifier.citationDe Looze, C., Williamson, W., Hirst, R., O'Connor, J., Knight, S., McCrory, C., Carey, D., Kenny, R.A., Impaired orthostatic heart rate recovery is associated with smaller thalamic volume: Results from The Irish Longitudinal Study on Aging (TILDA), Human Brain Mapping, 2020en
dc.identifier.issn1065-9471
dc.identifier.otherY
dc.identifier.urihttp://hdl.handle.net/2262/94685
dc.descriptionPUBLISHEDen
dc.description.abstractThe thalamus is a central hub of the autonomic network and thalamic volume has been associated with high‐risk phenotypes for sudden cardiac death. Heart rate response to physiological stressors (e.g., standing) and the associated recovery patterns provide reliable indicators of both autonomic function and cardiovascular risk. Here we examine if thalamic volume may be a risk marker for impaired heart rate recovery in response to orthostatic challenge. The Irish Longitudinal Study on Aging involves a nationally representative sample of older individuals aged ≥50 years. Multimodal brain magnetic resonance imaging and orthostatic heart rate recovery were available for a cross‐sectional sample of 430 participants. Multivariable regression and linear mixed‐effects models were adjusted for head size, age, sex, education, body mass index, blood pressure, history of cardiovascular diseases and events, cardiovascular medication, diabetes mellitus, smoking, alcohol intake, timed up‐and‐go (a measure of physical frailty), physical exercise and depression. Smaller thalamic volume was associated with slower heart rate recovery (−1.4 bpm per 1 cm3 thalamic volume, 95% CI −2.01 to −0.82; p < .001). In multivariable analysis, participants with smaller thalamic volumes had a mean heart rate recovery −2.7 bpm slower than participants with larger thalamic volumes (95% CI −3.89 to −1.61; p < .001). Covariates associated with smaller thalamic volume included age, history of diabetes, and heavy alcohol consumption. Thalamic volume may be an indicator of the structural integrity of the central autonomic network. It may be a clinical biomarker for stratification of individuals at risk of autonomic dysfunction, cardiovascular events, and sudden cardiac death.en
dc.language.isoenen
dc.publisherWileyen
dc.relation.ispartofseriesHuman Brain Mapping;
dc.rightsYen
dc.subjectAutonomic functionen
dc.subjectHeart rate recoveryen
dc.subjectThalamic volumeen
dc.titleImpaired orthostatic heart rate recovery is associated with smaller thalamic volume: Results from The Irish Longitudinal Study on Aging (TILDA)en
dc.typeJournal Articleen
dc.type.supercollectionscholarly_publicationsen
dc.type.supercollectionrefereed_publicationsen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/siknight
dc.identifier.peoplefinderurlhttp://people.tcd.ie/williawj
dc.identifier.peoplefinderurlhttp://people.tcd.ie/mccrorc
dc.identifier.peoplefinderurlhttp://people.tcd.ie/rkenny
dc.identifier.rssinternalid216139
dc.identifier.doihttp://dx.doi.org/10.1002/hbm.25022
dc.rights.ecaccessrightsopenAccess
dc.subject.TCDThemeAgeingen
dc.subject.TCDThemeNeuroscienceen
dc.subject.TCDTagNeuroscienceen
dc.identifier.rssurihttps://onlinelibrary.wiley.com/doi/full/10.1002/hbm.25022
dc.identifier.orcid_id0000-0003-1245-4870
dc.status.accessibleNen


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