Associations between neurocardiovascular signal entropy and physical frailty
File Type:
PDFItem Type:
Journal ArticleDate:
2021Access:
openAccessCitation:
Silvin P. Knight, Louise Newman, John D. O Connor, James Davis, Rose Anne Kenny, Roman Romero-Ortuno, Associations between neurocardiovascular signal entropy and physical frailty, Entropy, 2021Download Item:
Abstract:
In this cross-sectional study, the relationship between noninvasively measured neurocardiovascular signal entropy and physical frailty was explored in a sample of community-dwelling older adults from The Irish Longitudinal Study on Ageing (TILDA). The hypothesis under investigation was that dysfunction in the neurovascular and cardiovascular systems, as quantified by short-length signal complexity during a lying-to-stand test (active stand), could provide a marker for frailty. Frailty status (i.e., “non-frail”, “pre-frail”, and “frail”) was based on Fried’s criteria (i.e., exhaustion, unexplained weight loss, weakness, slowness, and low physical activity). Approximate entropy (ApEn) and sample entropy (SampEn) were calculated during resting (lying down), active standing, and recovery phases. There was continuously measured blood pressure/heart rate data from 2645 individuals (53.0% female) and frontal lobe tissue oxygenation data from 2225 participants (52.3% female); both samples had a mean (SD) age of 64.3 (7.7) years. Results revealed statistically significant associations between neurocardiovascular signal entropy and frailty status. Entropy differences between non-frail and pre-frail/frail were greater during resting state compared with standing and recovery phases. Compared with ApEn, SampEn seemed to have better discriminating power between non-frail and pre-frail/frail individuals. The quantification of entropy in short length neurocardiovascular signals could provide a clinically useful marker of the multiple physiological dysregulations that underlie physical frailty.
Sponsor
Grant Number
Science Foundation Ireland (SFI)
18/FRL/6188
Author's Homepage:
http://people.tcd.ie/romeroorhttp://people.tcd.ie/rkenny
http://people.tcd.ie/siknight
http://people.tcd.ie/lonewman
Description:
PUBLISHEDType of material:
Journal ArticleSeries/Report no:
EntropyAvailability:
Full text availableKeywords:
Approximate entropy, Sample entropy, Physical frailty, Cardiovascular, Neurovascular, Blood pressure, Heart rate, Frontal lobe oxygenation, Near infrared spectroscopy, NIRS, TILDASubject (TCD):
Ageing , NeuroscienceDOI:
https://www.mdpi.com/1099-4300/23/1/4Metadata
Show full item recordLicences: