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dc.contributor.authorBoylan, Fabio
dc.contributor.authorGiorno, Thais Biondino Sardella
dc.contributor.authordos Santos, Carlos Henrique Corrêa
dc.contributor.authorde Carvalho, Mario Geraldo
dc.contributor.authorda Silva, Virgínia Cláudia
dc.contributor.authorde Sousa Jr., Paulo Teixeria
dc.contributor.authorFernandes, Patricia Dias
dc.date.accessioned2020-01-15T15:33:27Z
dc.date.available2020-01-15T15:33:27Z
dc.date.issued2019
dc.date.submitted2019en
dc.identifier.citationGiorno, T.B.S., dos Santos, C.H.C., de Carvalho, M.G., da Silva, V.C., de Sousa, P.T., Fernandes, P.D. & Boylan, F., Study on the antinociceptive activity and mechanism of action of isolated saponins from siolmatra brasiliensis (Cogn.) Baill, Molecules, 24, 24, 2019en
dc.identifier.otherY
dc.identifier.urihttps://www.mdpi.com/1420-3049/24/24/4584
dc.identifier.urihttp://hdl.handle.net/2262/91332
dc.description.abstractInfusions of roots of Siolmatra brasiliensis (Cogn.) Baill, (“taiuiá”, “cipó-tauá”) are used for toothache pain and ulcers. We aimed to study the antinociceptive effects and identify the possible mechanism of action of this plant and its isolated substances (cayaponoside A1, cayaponoside B4, cayaponoside D, and siolmatroside I). Hydroethanol extract (HE), ethyl acetate fraction (EtOAc), and isolated saponins were evaluated in chemical and thermal models of pain in mice. Animals were orally pretreated and evaluated in the capsaicin- or glutamate-induced licking and in the hot plate tests. The antinociceptive mechanism of action was evaluated using the hot plate test with the following pretreatments: Atropine (cholinergic antagonist), naloxone (opioid antagonist), or L-NAME (nitric oxide synthase inhibitor). All extracts and isolated saponins increased the area under the curve in the hot plate test. Tested substances induced a higher effect than the morphine-treated group. Our data suggest that stems of S. brasiliensis and their isolated substances present antinociceptive effects. Cholinergic and opioidergic pathways seem to be involved in their mechanism of action. Taken together our data corroborate the traditional use of the plant and expands the information regarding its useen
dc.language.isoenen
dc.relation.ispartofseriesMolecules;
dc.relation.ispartofseries24;
dc.relation.ispartofseries24;
dc.rightsYen
dc.subjectSiolmatra brasiliensis (Cogn.) Baill, (“taiuiá”, “cipó-tauá”)en
dc.subjectAntinociceptive activityen
dc.subjectCayaponoside A1en
dc.subjectCayapanoside B4en
dc.subjectCayapanoside Den
dc.subjectSiolmatroside Ien
dc.subjectPainen
dc.subjectAnalgesiaen
dc.titleStudy on the antinociceptive activity and mechanism of action of isolated saponins from siolmatra brasiliensis (Cogn.) Baillen
dc.typeJournal Articleen
dc.type.supercollectionscholarly_publicationsen
dc.type.supercollectionrefereed_publicationsen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/desouzaf
dc.identifier.rssinternalid210060
dc.identifier.doihttp://dx.doi.org/10.3390/molecules24244584
dc.rights.ecaccessrightsopenAccess
dc.identifier.orcid_id0000-0001-5531-1787
dc.contributor.sponsorScience Foundation Ireland (SFI)en
dc.contributor.sponsorGrantNumberSFI/13/ISCA/2843en


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