Optimised oligonucleotide substrates to assay XPF-ERCC1 nuclease activity for the discovery of DNA repair inhibitors
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Journal ArticleDate:
2019Access:
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Thomas A.M., Brolih S., McGouran J.F., El-Sagheer A.H., Ptchelkine D., Jones M., McDonald N.Q., McHugh P.J., Brown T., Optimised oligonucleotide substrates to assay XPF-ERCC1 nuclease activity for the discovery of DNA repair inhibitors, Chemical Communications, 55, 78, 2019, 11671 - 11674Download Item:
Abstract:
We report the design and optimisation of novel oligonucleotide
substrates for a sensitive fluorescence assay for high-throughput
screening and functional studies of the DNA repair enzyme, XPFERCC1,
with a view to accelerating inhibitor and drug discovery.
URI:
https://pubs.rsc.org/en/content/articlelanding/2019/CC/C9CC05476F#!divAbstracthttp://hdl.handle.net/2262/91283
Author's Homepage:
http://people.tcd.ie/jmcgouraDescription:
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Author: Mcgouran, Joanna
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Journal ArticleURI:
https://pubs.rsc.org/en/content/articlelanding/2019/CC/C9CC05476F#!divAbstracthttp://hdl.handle.net/2262/91283
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Chemical Communications55
78
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Full text availableKeywords:
DNA repair, Chemotherapy, XPF-ERCC1DOI:
http://dx.doi.org/10.1039/c9cc05476fISSN:
1364548X 13597345Metadata
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