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dc.contributor.advisorO'Farrelly, Cliona
dc.contributor.authorCormican, Paul
dc.date.accessioned2019-11-05T15:11:48Z
dc.date.available2019-11-05T15:11:48Z
dc.date.issued2009
dc.identifier.citationPaul Cormican, 'A comparative genomics analysis of the vertebrate immune system : genes, pathways and evolution', [thesis], Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2009, pp 174
dc.identifier.otherTHESIS 10009
dc.identifier.urihttp://hdl.handle.net/2262/90056
dc.description.abstractAll species possess a selection-honed collection of genes whose products function in unison to form a barricade to invading pathogens. The exponential increase in publicly available sequence data has allowed the application of bioinformatics approaches to explore the conservation and variation of immune genes when compared between species. Antimicrobial peptides (AMPs) are important effector molecules of the immune response. Intra and inter genomic analysis indicates that, although AMPs are evolutionarily conserved across species, subgroups of gene lineages exist that are specific to certain species. We applied a Hidden Markov Model (HMM) profile search method to identification of the β-defensin family of AMPs in cattle and characterised the most greatly expanded gene family of any mammal thus far examined.
dc.format1 volume
dc.language.isoen
dc.publisherTrinity College (Dublin, Ireland). School of Biochemistry and Immunology
dc.relation.isversionofhttp://stella.catalogue.tcd.ie/iii/encore/record/C__Rb15349383
dc.subjectBiochemistry & Immunology, Ph.D.
dc.subjectPh.D. Trinity College Dublin.
dc.titleA comparative genomics analysis of the vertebrate immune system : genes, pathways and evolution
dc.typethesis
dc.type.supercollectionthesis_dissertations
dc.type.supercollectionrefereed_publications
dc.type.qualificationlevelDoctoral
dc.type.qualificationnameDoctor of Philosophy (Ph.D.)
dc.rights.ecaccessrightsopenAccess
dc.format.extentpaginationpp 174
dc.description.noteTARA (Trinity’s Access to Research Archive) has a robust takedown policy. Please contact us if you have any concerns: rssadmin@tcd.ie


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