Browsing Pharmacy and Pharmaceutical Sciences by Title
Now showing items 1-20 of 603
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2-(Di-phenyl-methyl-idene)-2,3-di-hydro-1H-inden-1-one.
(2013)In the title mol-ecule, C22H16O, the indanone ring system is approximately planar with a dihedral angle between the fused rings of 5.13 (14)°. Two benzene rings are linked together at one side of a double bond, sitting on ... -
A novel method for the measurement of flow-induced platelet activation at nanoscale resolution level
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2009)Background: Platelet aggregation Is essential for vascular haemostasis and thrombosis. Inhibition of platelet aggregation underpins the pharmacological and clinical effects of antiplatelet drugs. These effects are commonly ... -
A pharmacokinetic and clinical evaluation of antimicrobial drugs in critically ill patients during Continuous Venovenous Haemodifiltration (CVVHDF) therapy
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2007)Critically ill patients are at risk from sepsis requiring antimicrobial therapy and acute renal failure, which may require extracorporeal renal replacement therapy. The objective of this study was to quantify and assess ... -
A study of the release of the amphoteric drug amoxycillin from biodegradable polymers
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2000)Poly-alpha-hydroxy-aliphatic esters constitute a group of biodegradable polymers which have been actively investigated over the past three decades for the sustained release of drug compounds. A literature review revealed ... -
Absorption properties of non-steroidal anti-inflammatory drugs and their amino acid derivatives
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2003)The principal objectives of this work were: i) to examine the absorption properties of ibuprofen in a range of different buffer solutions; ii) to study the absorption properties and mechanisms of ibuprofen, ketoprofen and ... -
The acoustic features of inhalation can be used to quantify aerosol delivery from a Diskus? dry powder inhaler
(2014)Some patients are unable to generate the peak inspiratory flow rate (PIFR) necessary to de-agglomerate drug particles from dry powder inhalers (DPIs). In this study we tested the hypothesis that the acoustic parameters of ... -
Addressing the complexity of medication use in older people with intellectual disability
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2019)Background: People with intellectual disabilities (ID) experience high levels of polypharmacy and medication burden. Many of the most commonly occurring medical conditions in older adults with ID are treated with medications ... -
Adhesion characteristics and stability assessment of lectin-modified liposomes for site-specific drug delivery
(2008)Carbohydrate moieties of the cellular glycocalyx have been suggested to play an important role in biological recognition processes during pathologic conditions, such as inflammation and cancer. Herein, we describe ... -
Amorphous silica nanoparticles trigger nitric oxide/peroxynitrite imbalance in human endothelial cells inflammatory and cytotoxicity effects.
(2011)BACKGROUND: The purpose of this study was to investigate the mechanism of noxious effects of amorphous silica nanoparticles on human endothelial cells. METHODS: Nanoparticle uptake was examined by transmission electron ... -
Amorphous solid dispersions of ketoprofen and poly-vinyl polymers prepared via electrospraying and spray drying: A comparison of particle characteristics and performance.
(Elsevier, 2019-07-20)The purpose of this work was to compare the particle characteristics and dissolution performance of amorphous solid dispersions (ASDs) of ketoprofen and vinyl-pyrrolidone based polymers prepared using electrospraying and ... -
Amorphous solid dispersions of sulfonamide/Soluplus® and sulfonamide/PVP prepared by ball milling
(2013)The aim of this paper is to investigate the physicochemical properties of binary amorphous dispersions of poorly soluble sulfonamide/polymeric excipient prepared by ball milling. The sulfonamides selected were sulfathiazole ... -
An exploration of the role of community pharmacists in health promotion in Ireland
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2009)A combination of qualitative and quantitative methodologies was used to explore the research questions from a number of different angles. A literature review was carried out to identify work which had already been published ... -
An exploration of the role of community pharmacists in the supply of benzodiazepines and Z-drugs in Ireland
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2014)This thesis set out to explore community pharmacists' role in the supply of benzodiazepines and Z-drugs in Ireland. The introductory chapter outlines how the research undertaken sought to address a notable gap in the ... -
An investigation into the behavioural effects of polyamines, polyamine antagonsits and novel compounds in vivo
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2007)The polyamines, putrescine, spermidine and spermine are ubiquitous compounents of eukaryotric cells in nature and are found in high concentrations in brain tissue. Polyamines have been implicated in cell growth, differentiation ...
