Browsing Pharmacy and Pharmaceutical Sciences by Title
Now showing items 391-410 of 603
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Optimisation of pulmonary drug delivery of the model peptide drug, salmon calcitonin
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2011)The use of the pulmonary route is a viable alternative administration route to injection, in particular for drugs with poor systemic bioavailability upon oral delivery such as therapeutic peptides and proteins. However, ... -
Optimisation of spray drying process conditions for sugar nanoporous microparticles (NPMPs) intended for inhalation
(2011)The present study investigated the effect of operating parameters of a laboratory spray dryer on powder characteristics, in order to optimise the production of trehalose and raffinose powders, intended to be used as carriers ... -
Optimising the in vitro and in vivo performance of oral cocrystal formulations via spray coating
(2018)Engineering of pharmaceutical cocrystals is an advantageous alternative to salt formation for improving the aqueous solubility of hydrophobic drugs. Although, spray drying is a well-established scale-up technique in the ... -
Part Two: Evaluation of N-methylbupropion as a Potential Bupropion Prodrug
(2014)N-methylbupropion was selected as a potential prodrug from our in vitro screening of analogues of bupropion described in the preceding paper. This study describes in vivo pharmacokinetics of N-methylbupropion in the ... -
Particle engineering of materials for oral inhalation by dry powder inhalers. I - Particles of sugar excipients (trehalose and raffinose) for protein delivery
(2011)The pulmonary route of delivery offers a potential alternative to parenteral administration of peptides and proteins. Protection of protein structure is essential in both processing and storage of the final formulation. ... -
Particle engineering of materials for oral inhalation by dry powder inhalers. II - Sodium cromoglicate
(2011)Sodium cromoglicate is an antiasthmatic and antiallergenic drug used in inhalation therapy and commonly administered by a dry powder inhaler. In the present study we sought to examine the feasibility of producing nanoporous ... -
The particle has landed - characterizing the fate of inhaled pharmaceuticals
(2010)Although there is a modest body of literature on the absorption of inhaled pharmaceuticals by normal lungs and some limited information from diseased lungs, there is still a surprising lack of mechanistic knowledge about ... -
Patterns of Medication Use Associated with Epilepsy and Comorbid Behavioural and Mental Disorders in Older People with Intellectual Disability
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2022)Background: There is increasing concern worldwide regarding the levels of use and suboptimal prescribing of psychotropic medication in people with intellectual disability. Antipsychotics, in particular are often prescribed ... -
Pentacyclic triterpenes modulate farnesoid X receptor expression in colonic epithelial cells: implications for colonic secretory function.
(2022)The nuclear bile acid receptor, farnesoid X receptor (FXR), is an important regulator of intestinal and metabolic function. Previous studies suggest that pentacyclic triterpenes (PCTs), a class of plant-derived bioactive ... -
Personal Electronic Records of Medications (PERMs) for medication reconciliation at care transitions: a rapid realist review.
(2021)Background Medication reconciliation (MedRec), a process to reduce medication error at care transitions, is labour- and resource-intensive and time-consuming. Use of Personal Electronic Records of Medications (PERMs) ... -
Pharmaceutical cocrystals : a contribution to fundamental studies addressing solubility, dissolution, formation and characterisation
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2013)This thesis has focused on the study of pharmaceutical cocrystals. The investigations have addressed the solubility, dissolution and stability of cocrystals as well as the evaluation of selected production techniques, in ... -
Pharmaceutical policy - health strategy working paper
(2002)Working paper in response to govenment Health Strategy 'Quality and Fairness A health System for you'. It looks at the priority policy areas for development neglected in the Health Strategy; Community Pharmacy, Hospital ... -
Pharmaceutical services for patients in methadone treatment in Ireland and the introduction of the Methadone Protocol Scheme
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2002)Methadone is a long-acting opiate commonly used in substitution therapy for heroin addiction. In Ireland, prior to 1998, people requiring treatment for opiate addiction could either attend the National Drug Treatment Centre, ... -
Pharmaceutical Solid Forms and Formulations for Enhanced Solubility and Dissolution: Cocrystals, Salts, and Crystalline Solid Dispersions
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2024)This thesis focuses on the development, manufacture, and characterisation of cocrystals and salts and their formulations, to enhance the solubility and dissolution of poorly soluble drugs. Three poorly soluble active ... -
Pharmaceutical stability and prodrug studies on the antidepressant bupropion
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2010)This thesis describes the work carried out at the School of Pharmacy and Pharmaceutical Sciences, Trinity College on the pharmaceutical stability and prodrug studies on the antidepressant bupropion. Chapter 1 gives an ... -
Pharmacists involvement in COVID-19 vaccination across Europe: A situational analysis of current practice and policy
(2021)One year since the emergence of the COVID-19 pandemic, rapid response measures have been implemented internationally to mitigate the spread of the virus. Following rapid and successful pre-clinical and human trials, several ...
