Browsing Pharmacy and Pharmaceutical Sciences by Title
Now showing items 304-323 of 603
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A journey from ethnomedicine in rural Kenya to network pharmacology using a critical research approach
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2023)Background: Traditional medicine (TM) is widely practiced globally, with inter-country figures on usage ranging from 30 to 90%. Research on TM is conducted for a multiplicity of reasons, among them health care and ... -
Kinetic and structural studies of novel isosorbide-based ligand binding to esterase enzymes
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2009)The main goal of the project described herein was to examine and rationalise the binding of a novel class of compound based on isosorbide to cholinesterase enzymes. The compounds of interest had been prepared within the ... -
Liposomes as carriers for systemic delivery of salmon calcitonin by inhalation
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2011)The concept of delivering proteins and peptides to the systemic circulation via the lungs has been extensively investigated over the last 20 years. Main drivers for the approach are the lungs’ high surface area, presumed ... -
Long-term cytokine-free expansion of cord blood mononuclear cells in three-dimensional scaffolds
(2011)Cord blood expansion ex vivo can be achieved in liquid suspension through the addition of cytokines at the expense of often undesirable cell differentiation. In order to derive a cytokine-free dynamic culture system, we ... -
Manganese: a new contrast agent for lung imaging?
(2012)Lung parenchyma remains one of the most difficult tissues to be imaged by means of magnetic resonance imaging (MRI). Several MRI techniques are routinely used for lung imaging. However, manganese-enhancement MRI ... -
The manufacture of fixed dose combination products using advanced pharmaceutical techniques for the treatment of cardiovascular disease and type II diabetes
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2020)The thesis has focused on the use of continuous manufacturing techniques to produce fixed dose combination (FDC) products for the treatment of type II diabetes mellitus and cardiovascular diseases (CVDs). FDC products with ... -
Matrix metalloproteinase-9 modulates intestinal injury in rats with transmural colitis.
(2006)Proteolysis and degradation of extracellular matrix by metalloproteinases (MMPs) may contribute to intestinal injury in inflammatory bowel disease. In the present study, we investigated the pathogenic role of gelatinases ... -
Matrix metalloproteinases in inflammatory bowel disease: an update
(2015)Matrix metalloproteinases (MMPs) are known to be upregulated in inflammatory bowel disease (IBD) and other inflammatory conditions, but while their involvement is clear, their role in many settings has yet to be determined. ... -
Measuring and benchmarking safety culture: application of the safety attitudes questionnaire to an acute medical admissions unit.
(2009)Objectives: To assess the safety culture in an acute medical admissions unit (AMAU) of a teaching hospital in order to benchmark results against international data and guide a unit-based, integrated, risk management ... -
Mechanisms of aggregation inhibition by aspirin and nitrate-aspirin prodrugs in human platelets
(2012)OBJECTIVES: Aspirin is the mainstay of anti-platelet therapy in the secondary prevention of cardiovascular disease. However, problems with aspirin safety and resistance demand clinical strategies based on multiple ... -
Mechanisms of aggregation inhibition by aspirin and nitrate-aspirin prodrugs in human platelets.
(2012)Objectives Aspirin is the mainstay of anti-platelet therapy in the secondary prevention of cardiovascular disease. However, problems with aspirin safety and resistance demand clinical strategies based on multiple pharmacological ...
