Comparative genomics in yeasts
Citation:
Simon Wong, 'Comparative genomics in yeasts', [thesis], Trinity College (Dublin, Ireland). Department of Genetics, 2004, pp 151Download Item:
Abstract:
Comparative genomics allows us to delve into the fundamental differences among
species that form the basis of biodiversity, as well as the preservative forces of natural
selection that have left many things unchanged. It is important to understand how these
opposing influences ultimately shaped the genomes of today. The yeast
Saccharomyces cerevisiae and its relatively small, completely sequenced genome is an
ideal model eukaryote for such research. With the availability of sequence data from a
wide range of related yeasts, this study re-visited the controversial proposal that
S. cerevisiae is derived from an ancient polyploid. A novel technique of visualising
gene order data between species, 'proximity plots', was created. It uncovered extensive
duplicated regions in the S. cerevisiae genome that were previously undetected. The
organisation of these blocks reaffirmed the genome duplication hypothesis. Computer
simulation was used to predict post-polyploidisation gene order conservation under a
gradual diploidisation model, which can explain most of the observed data.
Author: Wong, Simon
Advisor:
Wolfe, KenQualification name:
Doctor of Philosophy (Ph.D.)Publisher:
Trinity College (Dublin, Ireland). Department of GeneticsNote:
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Full text availableKeywords:
Genetics, Ph.D., Ph.D. Trinity College DublinMetadata
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