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dc.contributor.advisorGardiner, Clair
dc.contributor.authorO'Connor, Geraldine
dc.date.accessioned2019-05-01T14:33:22Z
dc.date.available2019-05-01T14:33:22Z
dc.date.issued2007
dc.identifier.citationGeraldine O'Connor, 'Functional consequences of genetic polymorphism of the KIR3DL1/S1 receptor', [thesis], Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2007, pp 319
dc.identifier.otherTHESIS 8418
dc.identifier.urihttp://hdl.handle.net/2262/86559
dc.description.abstractNatural Killer (NK) cells are crucial effector cells of the innate immune system that function to eliminate virally infected and transformed cells. The activation of these cells is controlled in part by the expression of cell surface receptors including inhibitory receptors specific for HLA antigens. Expression of these inhibitory receptors allow s NK cells to become activated in the event of down-regulation or loss of HLA expression, as occurs in some viral infections and transformation events. One important family of HLA -specific receptors are killer immunoglobulin like receptors (KIR). The 3DL1 member of the family is a highly polymorphic receptor that recognises a range of HLA-B allotypes that contain the Bw4 public epitope.
dc.format1 volume
dc.language.isoen
dc.publisherTrinity College (Dublin, Ireland). School of Biochemistry and Immunology
dc.relation.isversionofhttp://stella.catalogue.tcd.ie/iii/encore/record/C__Rb13345532
dc.subjectBiochemistry, Ph.D.
dc.subjectPh.D. Trinity College Dublin
dc.titleFunctional consequences of genetic polymorphism of the KIR3DL1/S1 receptor
dc.typethesis
dc.type.supercollectionthesis_dissertations
dc.type.supercollectionrefereed_publications
dc.type.qualificationlevelDoctoral
dc.type.qualificationnameDoctor of Philosophy (Ph.D.)
dc.rights.ecaccessrightsopenAccess
dc.format.extentpaginationpp 319
dc.description.noteTARA (Trinity's Access to Research Archive) has a robust takedown policy. Please contact us if you have any concerns: rssadmin@tcd.ie


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