The relationship between Ascaris lumbricoides and malaria in children aged 1-4 years
Citation:
Patrick Kirwan, 'The relationship between Ascaris lumbricoides and malaria in children aged 1-4 years', [thesis], Trinity College (Dublin, Ireland). Department of Zoology, 2008, pp 288Download Item:
Abstract:
Soil-transmitted helminths (STH) are among the most prevalent of chronic human infections
worldwide. More than 1.2 billion people are thought to be infected with one or more species
of STH (de Silva et al., 2003). In nature, concomitant infections are the rule rather than the
exception (Cox, 2001). The interaction between helminths and malaria has gained
considerable attention from the scientific community (Basavaraju and Schantz, 2006; Mwangi
et al., 2007). Animal and human studies have shown that there is an association between
helminths and malaria (Spiegel et al., 2003; Helmby et al., 1998). The findings from studies
investigating these co-infections are contradictory: some studies have shown that co-infection
increases parasitaemia and clinical malaria (Briand et al., 2005), whereas others have shown
co-infection to have the opposite effect (Brutus et al., 2006). Most of the human studies are
observational in nature i.e. cross-sectional surveys (Tshikuka et al., 1996; Briand et al., 2005),
case-control studies (Nacher et al., 2000; Nacher et al., 2001c) or longitudinal studies that
monitor disease trends (Spiegel et al., 2003; Sokhna et al., 2004) and therefore fail to
demonstrate causality. The thesis presented here represents an investigation of the
relationship between soil-transmitted helminths and malaria in preschool children.
Author: Kirwan, Patrick
Advisor:
Holland, CeliaQualification name:
Doctor of Philosophy (Ph.D.)Publisher:
Trinity College (Dublin, Ireland). Department of ZoologyNote:
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Full text availableKeywords:
Zoology, Ph.D., Ph.D. Trinity College DublinMetadata
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