Browsing Genetics by Date of Publication
Now showing items 1-20 of 567
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Relationship among oxidative stress, growth cycle, and sporulation in Bacillus subtilis.
(1987)The sensitivity of Bacillus subtilis to hydrogen peroxide (oxidative stress) was found to vary with the position of the culture in the growth cycle. The most dramatic change occurred at the stationary phase, when the cells ... -
Oxidative stress and growth temperature in Bacillus subtilis.
(1987)Pretreatment of Bacillus subtilis with low concentrations of hydrogen peroxide protected the cells against the lethal effects of higher levels of oxidative stress. During the period of adaptation, eight proteins were ... -
CODON USAGE AND GENE-EXPRESSION LEVEL IN DICTYOSTELIUM-DISCOIDEUM - HIGHLY EXPRESSED GENES DO PREFER OPTIMAL CODONS
(1989)Codon usage patterns in the slime mould Dictyostelium discoideum have been re-examined (a total of 58 genes have been analysed). Considering the extreme A + T-richness of this genome (G + C = 22%), there is a surprising ... -
Replication and segregational stability of Bacillus plasmid pBAA1.
(1989)A cryptic plasmid, pBAA1, was identified in an industrial Bacillus strain. The plasmid is 6.8 kilobases in size and is present in cells at a copy number of approximately 5 per chromosome equivalent. The plasmid has been ... -
Novel therapeutic strategies for autosomal dominant retinitis pigmentosa
(Trinity College (Dublin, Ireland). School of Genetics and Microbiology, 2000)A major difficulty associated with the design of gene therapies for autosomal dominant diseases is the immense intragenic heterogeneity often encountered in such conditions. Two strategies which circumvent the difficulties ... -
Gene therapy strategies for dominant heterogeneous disorders and the identification of a novel gene causing retinitis pigmentosa and sensorineural deafness
(Trinity College (Dublin, Ireland). Department of Genetics, 2000)The purpose of this Ph.D. thesis has been to contribute towards the generation of therapies for inherited disorders such as retinitis pigmentosa (RP) and osteogenesis imperfecta (OI). In chapter 2, a novel mitochondrial ... -
Estimation of synteny conservation and genome compaction between pufferfish (Fugu) and human.
(2000)BACKGROUND: Knowledge of the amount of gene order and synteny conservation between two species gives insights to the extent and mechanisms of divergence. The vertebrate Fugu rubripes (pufferfish) has a small genome with ... -
A molecular genetic investigation of Irish origins
(Trinity College (Dublin, Ireland). Department of Genetics, 2000)Three hundred and ninety-four male DNA samples, from Ireland, Turkey and Togo, were genotyped for 5 X chromosome simple tandem repeat (STR) loci. Six Y chromosome STR loci and 8 Y chromosome unique event polymorphisms were ... -
Gene order evolution and genomic analyses of the model eukaryote, Saccharomyces cerevisiae, and other yeast species
(Trinity College (Dublin, Ireland). School of Genetics and Microbiology, 2000)The complete genome sequence of the yeast Saccharomyces cerevisiae can be used to form a clearer picture of the evolution of the diverse species of yeast and to construct a model of eukaryote genome evolution. In this study ... -
On the molecular genetics of retinal dystrophies and glaucoma
(Trinity College (Dublin, Ireland). Department of Genetics, 2000)The central aim of this thesis was the elucidation of the underlying molecular pathologies of inherited diseases of the eye. Previous linkage studies on a large Spanish kindred (family FA-84), segregating adRP, resulted ... -
On the development of animal models for degenerative retinal disease
(Trinity College (Dublin, Ireland). Department of Genetics, 2000)Retinitis pigmentosa (RP) is one of the leading causes of inherited blindness within the working population of many developed countries. There is presently no cure for this disorder. The projects outlined in this thesis ...
