Biophysical and immunological pathway endophenotyping of atopic dermatitis stratified for filaggrin mutations

Abstract

Atopic dermatitis (AD, eczema) is a common inflammatory skin disease, driven and modified by environmental, immunological and genetic factors. It is characterized clinically by inflammatory and pruritic skin lesions and pathologically by a cutaneous and systemic TH2 cell-dominant inflammatory response, disrupted epidermal barrier function and staphylococcus aureus colonization.