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dc.contributor.advisorScanlan, Eoin
dc.contributor.authorBourke, Jean
dc.date.accessioned2017-02-23T15:04:06Z
dc.date.available2017-02-23T15:04:06Z
dc.date.issued2014
dc.identifier.citationJean Bourke, 'The synthesis and biological evaluation of Mycobacterium tuberculosis associated glycan derivatives', [thesis], Trinity College (Dublin, Ireland). School of Chemistry, 2014, pp 324
dc.identifier.otherTHESIS 10706
dc.identifier.urihttp://hdl.handle.net/2262/79491
dc.description.abstractMycobacterium tuberculosis establishes chronic infection and causes disease through manipulation of the host's innate and adaptive immune response. The bacterial cell wall is highly complex and contains a rich variety of glycosylated compounds, some of which are secreted during infection and have been proposed as immunomodulatory molecules. Amongst the most important of these are the p-hydroxybenzoic acid derivatives (p-HBADs) and phenolic glycolipids (PGLs). Herein is reported a synthetic methodology for the synthesis of these important biomolecules and their unnatural analogues and also the first in vitro study of the immunomodulatory effects of p-HBADs in isolation from the host bacterium.
dc.format1 volume
dc.language.isoen
dc.publisherTrinity College (Dublin, Ireland). School of Chemistry
dc.relation.isversionofhttp://stella.catalogue.tcd.ie/iii/encore/record/C__Rb16188981
dc.subjectChemistry, Ph.D.
dc.subjectPh.D. Trinity College Dublin
dc.titleThe synthesis and biological evaluation of Mycobacterium tuberculosis associated glycan derivatives
dc.typethesis
dc.type.supercollectionthesis_dissertations
dc.type.supercollectionrefereed_publications
dc.type.qualificationlevelDoctoral
dc.type.qualificationnameDoctor of Philosophy (Ph.D.)
dc.rights.ecaccessrightsopenAccess
dc.format.extentpaginationpp 324
dc.description.noteTARA (Trinity’s Access to Research Archive) has a robust takedown policy. Please contact us if you have any concerns: rssadmin@tcd.ie


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