Design, synthesis and biochemical evaluation of novel antiproliferative agents for the treatement of Burkitt's Lymphoma

Abstract

This thesis is concerned with the identification of novel antiproliferative agents for the treatment of Burkitt's lymphoma (BL), an aggressive B-cell malignancy. Numerous SERT and NET ligand such as SSRIs and TCAs, having been shown to induce cell death in BL cell lines. By exploiting the pro-apoptotic capabilities of these monoamine transporter targeting compounds, potential drug candidates for the treatment of BL could be identified. This thesis examines this subject over four chapters.