Formulation, production and biointeraction of micro and nano particulates with potential for use in drug delivery

Abstract

The current study involved the preparation of a range of micro and nano particulates from known biocompatible pharmaceutical polymeric excipients: PLGA, chitosan and hyaluronic acid, using physical rather than chemical processes and evaluates the various aspects of their drug delivery potential, biointeraction and potential toxicity. Emulsion techniques, including the double emulsion and single emulsion technique, are methods usually used in the manufacture of drug loaded PLGA (RG504) particles, as well as chitosan-PLGA particles. Cationically modified PLGA particles can efficiently bind the negatively charged DNA electrostatically, by using chitosan as adjuvant (Kumbar et al., 2002). Although release studies of proteins and drugs have been reported by numerous groups (Pean et al., 1998; Dunne et al., 2000; Gallagher and Corrigan 2000), there were large differences between the results. Therefore it is deemed necessary to explain the differences and conclude on the effects.