Cytokine-induced epithelial-mesenchymal transition : mechanisms and implications for fibrotic diseases of respiratory and intestinal epithelia
Citation:
Stephen Buckley, 'Cytokine-induced epithelial-mesenchymal transition : mechanisms and implications for fibrotic diseases of respiratory and intestinal epithelia', [thesis], Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2010, pp 183Download Item:
Abstract:
Fibrosis is characterised by the accumulation of myofibroblasts, the key effector cell implicated in the fibrogenic reaction. The exact origin of these myofibroblasts remains poorly understood. However, growing evidence suggests that a significant portion of synthetically active myofibroblasts arise from the conversion of epithelial cells through the process of epithelial-mesenchymal transition (EMT). During EMT, the cell-cell adhesion structures of epithelial cells are down-regulated, their cytoskeleton is reorganised and they become more motile, reflecting transition to a mesenchymal phenotype. This PhD project sought to greater characterise EMT and provide additional insights into potential mechanisms underlying this process.
Author: Buckley, Stephen
Advisor:
Ehrhardt, CarstenQualification name:
Doctor of Philosophy (Ph.D.)Publisher:
Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical SciencesNote:
TARA (Trinity’s Access to Research Archive) has a robust takedown policy. Please contact us if you have any concerns: rssadmin@tcd.ieType of material:
thesisCollections
Availability:
Full text availableMetadata
Show full item recordLicences: