dc.contributor.advisor | Healy, Anne-Marie | |
dc.contributor.advisor | Corrigan, O.I. | |
dc.contributor.author | Adamczyk, Bożena E. | |
dc.date.accessioned | 2016-11-24T16:36:11Z | |
dc.date.available | 2016-11-24T16:36:11Z | |
dc.date.issued | 2012 | |
dc.identifier.citation | Bożena E. Adamczyk, 'Development of microemulsions and self-emulsifying systems for oral drug delivery', [thesis], Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2012, pp 336 | |
dc.identifier.other | THESIS 10095 | |
dc.identifier.uri | http://hdl.handle.net/2262/77843 | |
dc.description.abstract | The main aim of the current work was to explore microemulsions (ME) and self- emulsifying lipid formulations (SELFs) comprising derivatives of capric/caprylic acids (Captex 355, Captex 200P, Capmul PG-8, Capmul MCM) as drug delivery systems for oral administration of hydrophilic compounds (BCS class III) intended for encapsulation.
Physicochemical profiling of hydrophilic model compounds (two bisphosphonates: sodium alendronate trihydrate and disodium pamidronate pentahydrate and a decaptide, acyline monoacetate) was carried out. Sodium alendronate trihydrate and disodium pamidronate pentahydrate were found to be highly water soluble with the highest solubility achieved in the modified K-Mcllvaine’s buffers pH 7.8 (~52 mg/ml) and pH 4.4 (~70 mg/ml) respectively. Acyline monoacetate was found to be also highly water soluble, however rapid gelation (physical instability) was observed in aqueous solutions. Good solubility (up to 10 mg/g) and physical stability (lack of gelling) was observed in propylene glycol and the standard GIPET® II formulation. The isoelectric point of acyline was found to be ~11.4. | |
dc.format | 1 volume | |
dc.language.iso | en | |
dc.publisher | Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences | |
dc.relation.isversionof | http://stella.catalogue.tcd.ie/iii/encore/record/C__Rb15355170 | |
dc.subject | Pharmacy & Pharmaceutical Sciences, Ph.D. | |
dc.subject | Ph.D. Trinity College Dublin | |
dc.title | Development of microemulsions and self-emulsifying systems for oral drug delivery | |
dc.type | thesis | |
dc.type.supercollection | thesis_dissertations | |
dc.type.supercollection | refereed_publications | |
dc.type.qualificationlevel | Doctoral | |
dc.type.qualificationname | Doctor of Philosophy (Ph.D.) | |
dc.rights.ecaccessrights | openAccess | |
dc.format.extentpagination | pp 336 | |
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