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dc.contributor.advisorHealy, Anne-Marie
dc.contributor.advisorCorrigan, O.I.
dc.contributor.authorAdamczyk, Bożena E.
dc.date.accessioned2016-11-24T16:36:11Z
dc.date.available2016-11-24T16:36:11Z
dc.date.issued2012
dc.identifier.citationBożena E. Adamczyk, 'Development of microemulsions and self-emulsifying systems for oral drug delivery', [thesis], Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2012, pp 336
dc.identifier.otherTHESIS 10095
dc.identifier.urihttp://hdl.handle.net/2262/77843
dc.description.abstractThe main aim of the current work was to explore microemulsions (ME) and self- emulsifying lipid formulations (SELFs) comprising derivatives of capric/caprylic acids (Captex 355, Captex 200P, Capmul PG-8, Capmul MCM) as drug delivery systems for oral administration of hydrophilic compounds (BCS class III) intended for encapsulation. Physicochemical profiling of hydrophilic model compounds (two bisphosphonates: sodium alendronate trihydrate and disodium pamidronate pentahydrate and a decaptide, acyline monoacetate) was carried out. Sodium alendronate trihydrate and disodium pamidronate pentahydrate were found to be highly water soluble with the highest solubility achieved in the modified K-Mcllvaine’s buffers pH 7.8 (~52 mg/ml) and pH 4.4 (~70 mg/ml) respectively. Acyline monoacetate was found to be also highly water soluble, however rapid gelation (physical instability) was observed in aqueous solutions. Good solubility (up to 10 mg/g) and physical stability (lack of gelling) was observed in propylene glycol and the standard GIPET® II formulation. The isoelectric point of acyline was found to be ~11.4.
dc.format1 volume
dc.language.isoen
dc.publisherTrinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences
dc.relation.isversionofhttp://stella.catalogue.tcd.ie/iii/encore/record/C__Rb15355170
dc.subjectPharmacy & Pharmaceutical Sciences, Ph.D.
dc.subjectPh.D. Trinity College Dublin
dc.titleDevelopment of microemulsions and self-emulsifying systems for oral drug delivery
dc.typethesis
dc.type.supercollectionthesis_dissertations
dc.type.supercollectionrefereed_publications
dc.type.qualificationlevelDoctoral
dc.type.qualificationnameDoctor of Philosophy (Ph.D.)
dc.rights.ecaccessrightsopenAccess
dc.format.extentpaginationpp 336
dc.description.noteTARA (Trinity’s Access to Research Archive) has a robust takedown policy. Please contact us if you have any concerns: rssadmin@tcd.ie


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