Replication of a distinct psoriatic arthritis risk variant at the IL23R locus

Abstract

Psoriatic arthritis (PsA) is a chronic inflammatory arthritis associated with the presence of psoriasis. Although the majority of PsA genetic risk loci identified also confer risk for psoriasis, the difference in heritability between the two diseases suggests that there remain uncovered risk loci that are associated with PsA but not psoriasis (herein called PsA-specific loci).1