Browsing Trinity College Dublin Theses & Dissertations by Title
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Neuroenchancement in normal ageing : preserving cognitive status through pharmacological interventions
(Trinity College (Dublin, Ireland). School of Psychology, 2012)The preclinical work presented here seeks to establish an enhancement of memory functions in healthy ageing rats via the manipulation of behavioural tasks. This series of studies compared behavioural deficits between ... -
Neuroimaging correlates of disability in Motor Neuron Disease
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2024)Motor neuron diseases (MND) clinically present with a wide variety of motor and extra-motor symptoms. However, the pathological correlates of such symptom manifestation and their progression is poorly understood. In the ... -
Neuroimaging features of Amyotrophic Lateral Sclerosis
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2024)Novelty: Because the vast majority of ALS imaging studies focus on evaluating motor pathology, the focus and novelty of this work is the nuanced characterisation of extra-motor involvement in a genetically stratified cohort ... -
The Neuroimaging Features of Frontotemporal Dementia: Characterising Phenotype-Associated Pathological Changes In Vivo
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2023)Frontotemporal dementia (FTD) is a rare type of dementia. It can affect language, behaviour and memory depending on what part of the brain is involved. It can be difficult to diagnose, especially in the early stages of ... -
Neuroimaging to Assess Neonatal Brain Development and Brain Injury in Neonatal Encephalopathy
(Trinity College Dublin. School of Medicine. Discipline of Psychiatry, 2023)Neonatal encephalopathy (NE) is a clinical syndrome describing perinatal brain injury and neurological dysfunction in the term-born infant. Magnetic resonance imaging (MRI) is a widely used tool in the assessment of NE, ... -
Neuroimmune activation in arthritic and neuropathic low back pain : implications for interventional therapies
(Trinity College (Dublin, Ireland). Department of Physiology, 2014)Chronic pain involves a progressive disturbance of mood, sleep and physical function, with significant medical, social and economic consequences. The mechanism by which acute pain may become chronic and refractory to ... -
Neuronal Nitric oxide synthase : a novel target for antidepressant activity
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2012)Major depressive disorder (MDD) is one of the most common psychiatric disorders and its origin has been attributed to dysfunction of the monoamine systems, particularly noradrenergic and serotonergic, making them the main ... -
Neurons, networks, and behaviour: Investigating multiscale interactions between brain regions and their behavioural correlates
(Trinity College Dublin. School of Psychology. Discipline of Psychology, 2024)Understanding the interactions between different brain regions is vital for unravelling the complexities of brain disorders and brain functions such as cognition, behaviour, and memory. While previous investigations of ... -
Neurophysiological changes associated with olfactory short-term habituation in Drosophilia melanogaster
(Trinity College (Dublin, Ireland). Department of Genetics, 2016)The term habituation describes a simple form of learning that is characterized by a behavioural response decrement following repeated or prolonged sensory stimulation (Christoffersen, 1997; Rankin et al, 2009; Thompson and ... -
Neuropsychological and electrophysiological correlates of self- and error-awareness in focal lesion patients and young adults
(Trinity College (Dublin, Ireland). School of Psychology, 2009)This thesis examines numerous aspects of deficit awareness, both among nonneurological participants and patients with circumscribed neural injury, in order to increase our understanding of the neuropsychological, neuroanatomical ... -
The Neuropsychological and Neurophysiological Signatures of Age-Related Differences in Mind-Wandering
(Trinity College Dublin. School of Psychology. Discipline of Psychology, 2021)Our inner mental life is subject to a constant, discursive, dynamically evolving stream of thoughts. Mind-wandering is the mind s default state, occupying up to half of all conscious cogitations, during which our thoughts ... -
Neuropsychological and Neuropsychiatric Endophenotypes in Amyotrophic Lateral Sclerosis
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2022)Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease, characterized by progressive muscle weakness and death, usually within 3-5 years from symptom onset. ALS is now recognized to be a multi-system ... -
Neuropsychosocial predictors of outcomes in opioid dependent patients post-detoxification
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2015)The current treatment of choice for most opiate dependent persons is long term substitute prescribing. Detoxification is not an effective stand-alone treatment. Given the weak evidence base for detoxification coupled with ... -
Neurotransmitter interactions in the control of spatial memory and exploratory activity in the rat
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Pharmacology & Therapeutics, 2006)The role of the central cholinergic system in learning and memory is well established, with many investigations reporting that central cholinergic hypofunction is correlated with impaired performance on various behavioural ... -
Neurotrophin mRNA expression in the central nervous system of the brain stem-spinal cord regenerating model, Anguilla anguilla, the European eel
(Trinity College (Dublin, Ireland). Department of Zoology, 2007)Neuronal regeneration is extremely limited in the central nervous system (CNS) of mature amniotes. On the other hand, many anamniotes, such as some fish, display rapid morphological and functional recovery after CNS injury, ... -
Neutrophil-derived proteases act as global regulators of IL-1 family cytokine activation states
(Trinity College (Dublin, Ireland). Department of Genetics, 2016)IL-1 family cytokines are pleiotropic cytokines capable of eliciting robust proinflammatory cytokine and chemokine secretion from a broad variety of cell types and tissues. Recent evidence has strongly implicated IL-36 ... -
New Approaches to the treatment of Schizophrenia and other Neuropsychiatric Disorders: Targeting alpha2-adrenoceptors
(Trinity College Dublin. School of Chemistry. Discipline of Chemistry, 2019)Schizophrenia is a severe mental illness affecting 21 million people worldwide, resulting in cognitive impairments and negative symptoms that impact patients' ability to live a normal life. Almost all current antipsychotic ... -
New biochips for a three-dimensional study of transendothelial leukocyte migration
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2011)An important step in the inflammatory response is the recruitment of leukocytes into tissues through the endothelial cells which line blood vessels. Transendothelial migration (TEM) is the result of a multistep cascade in ... -
New boundaries of justice in a world in motion : assessing the impact of global citizens in the Irish District Court
(Trinity College (Dublin, Ireland). School of Social Work and Social Policy, 2011)Although empirical research lends little support for the perceived immigration- crime nexus, it is an enduring perception. This thesis considers the impact of immigration on the Irish criminal courts. Ireland experienced ... -
New carbon nanotube composites
(Trinity College (Dublin, Ireland). School of Chemistry, 2006)The main goal of this research is to prepare new chemically functionalised carbon nanotubes and their composite materials and to investigate their properties. This work is focused on the use of organometallic chemistry for ...
