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dc.contributor.authorO'FARRELLY, CLIONAen
dc.date.accessioned2015-12-09T11:43:33Z
dc.date.available2015-12-09T11:43:33Z
dc.date.issued2007en
dc.date.submitted2007en
dc.identifier.citationGolden-Mason, L, Castelblanco, N, O'Farrelly, C, Rosen, HR, Phenotypic and functional changes of cytotoxic CD56pos natural T cells determine outcome of acute hepatitis C virus infection., Journal of virology, 81, 17, 2007, 9292 9298en
dc.identifier.otherYen
dc.identifier.urihttp://hdl.handle.net/2262/75161
dc.descriptionPUBLISHEDen
dc.description.abstractInnate CD56(pos) natural killer (NK) and natural T (NT) cells comprise important hepatic antiviral effector lymphocytes whose activity is fine-tuned through surface NK receptors (NKRs). Dysregulation of NKRs in patients with long-standing hepatitis C virus (HCV) infection has been shown, but little is known regarding NKRs in acute infection. Treatment-naïve patients with acute HCV (n = 22), including 10 with spontaneous recovery, were prospectively studied. CD56(pos) NT levels were reduced early in acute HCV infection and did not fluctuate over time. In resolving HCV infection, NT cells with a more activated phenotype (lower CD158A and higher natural cytotoxicity receptor expression) at baseline predated spontaneous recovery. Moreover, NKG2A expression on CD56(+) NT cells correlated directly with circulating HCV RNA levels. Deficient interleukin-13 (IL-13) production by NT cells and reduced IL-2-activated killing (LAK) at baseline were associated with the ultimate development of persistence. These results indicate a previously unappreciated role for NT cells in acute HCV infection and identify a potential target for pharmacologic manipulation.en
dc.description.sponsorshipWe thank the patients for their time and willingness to participate in this study and Jared Klarquist for technical assistance. This work was supported by RO1 DK060590 and U19 A 1066328-01 (HCV Center grant). We declare that we have no competing interests.en
dc.format.extent9292-9298en
dc.relation.ispartofseriesJournal of virologyen
dc.relation.ispartofseries81en
dc.relation.ispartofseries17en
dc.rightsYen
dc.subjectInnate CD56(pos) natural killer (NK) and natural T (NT) cellsen
dc.subject.lcshInnate CD56(pos) natural killer (NK) and natural T (NT) cellsen
dc.titlePhenotypic and functional changes of cytotoxic CD56pos natural T cells determine outcome of acute hepatitis C virus infection.en
dc.typeJournal Articleen
dc.type.supercollectionscholarly_publicationsen
dc.type.supercollectionrefereed_publicationsen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/ofarreclen
dc.identifier.rssinternalid54027en
dc.identifier.doihttp://dx.doi.org/10.1128/JVI.00834-07en
dc.rights.ecaccessrightsopenAccess
dc.subject.TCDThemeImmunology, Inflammation & Infectionen
dc.identifier.rssurihttp://www.pubmedcentral.nih.gov/picrender.fcgi?artid=1951454&blobtype=pdfen


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