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dc.contributor.authorMOLLOY, ANNEen
dc.date.accessioned2015-12-09T11:32:25Z
dc.date.available2015-12-09T11:32:25Z
dc.date.issued2011en
dc.date.submitted2011en
dc.identifier.citationCampoy C, Escolano-Margarit MV, Ramos R, Parrilla-Roure M, Csábi G, Beyer J, Ramirez-Tortosa MC, Molloy AM, Decsi T, Koletzko BV, Effects of prenatal fish-oil and 5-methyltetrahydrofolate supplementation on cognitive development of children at 6.5 y of age., The American journal of clinical nutrition, 94, 6 Suppl, 2011, 1880S-1888Sen
dc.identifier.issn0002-9165en
dc.identifier.otherYen
dc.identifier.urihttp://hdl.handle.net/2262/75132
dc.descriptionPUBLISHEDen
dc.description.abstractBackground: The influence of prenatal long-chain polyunsaturated fatty acids (LC-PUFAs) and folate on neurologic development re- mains controversial. Objective: The objective was to assess the long-term effects of n 2 3 (omega-3) LC-PUFA supplementatio n, 5-methyltetrahydrofolate (5-MTHF) supplementation, or both in pregnant women on cogni- tive development of offspring at 6.5 y of age. Design: This was a follow-up study of the NUHEAL (Nutraceuticals for a Healthier Life) cohort. Healthy pregnant women in 3 European centers were randomly assigned to 4 intervention groups. From the 20th week of pregnancy until delivery, they received a daily supplement of 500 mg docosahexaenoic acid (DHA) + 150 mg eicosapentaenoic acid [fish oil (FO)], 400 l g 5-MTHF, or both or a placebo. Infants received formula containing 0.5% DHA and 0.4% arachidonic acid (AA) if they were born to mothers r eceiving FO supplements or were virtually free of DHA and AA until the age of 6 mo if they belonged to the groups that were not supplement ed with FO. Fatty acids and folate concentrations were determined in maternal blood at weeks 20 and 30 of pregnancy, at delivery, and in cord blood. Cognitive function was assessed at 6.5 y of age with the K aufman Assessment Battery for Children (K-ABC). Results: We observed no significant differences in K-ABC scores between intervention groups. Higher DHA in maternal erythrocytes at delivery was associated with a Mental Processing Composite Score higher than the 50th percentile in the offspring. Conclusion: We observed no significant effect of supplementation on the cognitive function of children, but maternal DHA status may be related to later cognitive function in children. This trial was registered at clinicaltrials.gov as NCT01180933. Am J Clin Nutr 2011;94(suppl):1880S–8Sen
dc.description.sponsorshipSupported in part by the Commission of the European Community– specific Research and Technological Development Programme, “Quality of Life and Management of Living Resources,” within the 5th Framework Programme [contract no. QLK1-CT-1999-00888 NUHEAL (Nutraceuticals for a healthier life)] and within the 6th Framework Programme [Priority 5.4.en
dc.format.extent1880S-1888Sen
dc.relation.ispartofseriesThe American journal of clinical nutritionen
dc.relation.ispartofseries94en
dc.relation.ispartofseries6 Supplen
dc.rightsYen
dc.subjectneurologic developmenten
dc.subject.lcshneurologic developmenten
dc.titleEffects of prenatal fish-oil and 5-methyltetrahydrofolate supplementation on cognitive development of children at 6.5 y of age.en
dc.typeJournal Articleen
dc.type.supercollectionscholarly_publicationsen
dc.type.supercollectionrefereed_publicationsen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/amolloyen
dc.identifier.rssinternalid84426en
dc.identifier.doihttp://dx.doi.org/10.3945/ajcn.110.001107en
dc.rights.ecaccessrightsopenAccess
dc.subject.TCDThemeInternational Developmenten
dc.identifier.orcid_id0000-0002-1688-9049en


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