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Neuromedin U alters bioenergetics and expands the cancer stem cell phenotype in HER2-positive breast cancer

O'Driscoll, Lorraine; Porter, Richard; Martinez, Vanesa G.; Crown, John (2017)

Neuromedin U (NmU) is a neuropeptide belonging to the neuromedin family. Recently, we reported a significant association between NmU and breast cancer, particularly correlating with increased aggressiveness, resistance to ...

Resistance to HER2-targeted anti-cancer drugs is associated with immune evasion in cancer cells and their derived extracellular vesicles

O'Driscoll, Lorraine; Martinez, Vanesa G.; O'Neill, Sadhbh; Salimu, Josephine; Breslin, Susan; Clayton, Aled; Crown, John (2017)

Neuromedin U (NmU) -a neuropeptide belonging to the neuromedin family– plays a substantial role in HER2-positive breast cancer, correlating with increased aggressiveness, resistance to HER2-targeted therapies and overall ...