Search
Now showing items 1-10 of 17
Potential for alcohol and drug interactions in older adults: evidence from the Irish longitudinal study on ageing
(2014)
Background
Older adults are susceptible to adverse effects from the concomitant use of prescription medications and alcohol. This study estimates the prevalence of exposure to alcohol interactive (AI) medications and ...
Generic Drugs
(2008)
Isosorbide-based cholinesterase inhibitors; replacement of 5-ester groups leading to increased stability
(2010)
Isosorbide-2-carbamate-5-esters are highly potent and selective butyrylcholinesterase inhibitors with potential utility in the treatment of Alzheimer?s Disease (AD). They are stable in human plasma but in mouse plasma they ...
Novel isosorbide di-ester compounds as inhibitors of acetylcholinesterase
(2008)
We report herein that a variety of isosorbide di-esters, previously reported to be novel substrates for butyrylcholinesterase (BuChE, EC 3.1.1.8), are in fact inhibitors of the homologous enzyme acetylcholinesterase (AChE), ...
Synthesis, screening and pharmacokinetic evaluation of potential prodrugs of bupropion
(2014)
In general, prodrugs are developed to circumvent deficiencies associated with the absorption, distribution, metabolism, excretion or toxicological (ADMET) profile associated with the active drug. In our study, we select ...
A role for adenosine A1 receptor blockade in the ability of caffeine to promote MDMA "Ecstasy"-induced striatal dopamine release
(2011)
Co-administration of caffeine profoundly enhances the acute toxicity of 3,4 methylenedioxymethamphetamine (MDMA) in rats. The aim of this study was to determine the ability of caffeine to impact upon MDMA-induced dopamine ...