Fatty acids are considered to be useful as carrier materials in the formulation of drug delivery systems. Literature on fatty acid systems, in particular, stearic acid, was reviewed, though in general, research in this ...

There are five chapters presented in this thesis. The first chapter deals with development and validation of a HPLC method for the analysis of MDMA in illicitly produced Ecstasy tablets. In all 100 tablets were analysed ...

The polyamines, spermine and spermidine, are ubiquitous in nature but are found in especially high concentrations in brain tissue. The polyamines are required for cell growth and differentiation but in high doses are ...

This thesis is presented in four sections. In the first section the synthesis of a series of B ring derivatives of dehydroepiandrosterone (DHEA) is described. DHEA is the most abundant steroid in human plasma and has been ...

Anticoagulant therapy is used to reduce the embolic risk associated with many diseases e.g. atrial fibrillation, deep vein thrombosis and aortic valve replacement. The decision to anticoagulate a patient is made individually, ...

Methadone is a long-acting opiate commonly used in substitution therapy for heroin addiction. In Ireland, prior to 1998, people requiring treatment for opiate addiction could either attend the National Drug Treatment Centre, ...

3,4-Methylenedioxymethamphetamme (MDMA, Ecstasy) and other, so-called, designer amphetamines, have become popular drugs of abuse over the past number of years. Detailed knowledge of the synthetic methods employed by ...

The experiments in this thesis represent biopharmaceutical investigations, performed in an attempt to evaluate potential dosage form strategies designed to promote the intestinal lymphatic transport of lipophilic compounds. ...

The aim of this thesis was to develop a number of novel products for use in the oral cavity. Periodontitis is a condition characterized by the loss of clinical attachment to the gum, along with resorption of the alveolar ...