RSS 1.0TCIN (Trinity College Institute of Neuroscience) Scholarly Publications
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Delineating the impact of executive dysfunction on social cognition for patients and caregivers in Amyotrophic Lateral Sclerosis
(Trinity College (Dublin, Ireland). Institute of Neuroscience, 2016)Amyotrophic Lateral Sclerosis (ALS) is a rapidly progressive neurodegenerative disease that implicates both motor and cognitive function, and is the most prevalent Motor Neuron Disease (MND). ALS is a clinically heterogeneous ... -
Development of a microelectrode array biosensor platform for the study of neuronal function
(Trinity College (Dublin, Ireland). Institute of Neuroscience, 2016)The impact of brain disorders on the human population is significant, with neuropsychiatric illness, and in particular mood and psychotic disorders, contributing to over 25% of the 800 billion euro annual healthcare costs ... -
The role of innate immune cells in the pathogenesis of experimental autoimmune encephalomyelitis
(Trinity College. Institute of Neuroscience, 2015)Experimental autoimmune encephalomyelitis (EAE) is a widely exploited animal model of multiple sclerosis (MS) and is a valuable tool in understanding the cellular and molecular basis of autoimmunity and inflammation in the ... -
Non-single quantum MRI : a cardiac modulated rhythm in the brain tissue
(Trinity College. Institute of Neuroscience, 2016)The relation between pressure and ow is one of the key concepts to understand brain dynamics. The Navier-Stokes equations state how changes in flow are related to changes in pressure. In addition, the Monro-Kellie hypothesis ... -
An investigation into stress response axis, serotonin system and adaptive immunity in depression : a focus on early life adversity and epigenetic mechanisms
(Trinity College. Institute of Neuroscience, 2017)Major depressive disorder (MDD) is a debilitating psychiatric illness that affects at least 350 million individuals worldwide. Despite its high prevalence rate and its large global disease burden, the biological mechanisms ... -
An investigation of kynurenine pathway metabolism, the hypothalamic-pituitary-adrenal axis, and inflammatory markers in Major Depressive Disorder
(Trinity College. Institute of Neuroscience, 2017)Major Depressive Disorder (MDD) is a debilitating mental health problem with a lifetime prevalence rate of more than 16%. Despite its prevalence, a biological mechanism accounting for all aspects of the disorder has yet ... -
A Langevin equation approach to diffusion magnetic resonance imaging
(Trinity College. Institute of Neuroscience, 2010)Diffusion-weighted magnetic resonance imaging (DW MRI) is a noninvasive technique which is sensitive to the translational motion of water molecules because of their Brownian motion, allowing us to probe the microstructure ... -
Bolus-tracking arterial spin labeling : a new approach to quantifying cerebral perfusion with magnetic resonance imaging
(TCIN (Trinity College Institute of Neuroscience) Scholarly Publications, 2009)The body of work presented herein describes the development a new technique for the quantification of cerebral perfusion, termed bolus-tracking arterial spin labeling (btASL). The technique uses a novel non-compartmental ... -
Endocannabinoids and Notch-1 signalling in an in-vitro model of Alzheimer's disease and with normal aging
(Trinity College. Institute of Neuroscience, 2013)Notch is a universal arbiter of cell fate decision during development and in the adult brain. Aberrant Notch signaling has recently emerged as a possible mechanism that underlies altered neurogenesis, cognitive impairments, ... -
A population-based longitudinal study of cognitive and behavioural impairment in ALS
(Trinity College. Institute of Neuroscience, 2011)Amyotrophic Lateral Sclerosis is the most common neurodegenerative disorder of young and middle-aged adults. Convergent research from the disciplines of neuroimaging, neuropathology, genetics and neuropsychology now points ... -
Endocannabinoids and neuroprotection in an in vitro model of Alzheimer's disease
(Trinity College. Institute of Neuroscience, 2010)Alzheimer’s disease (AD) is a neurodegenerative disease characterised by the progressive deterioration of cognition and memory as a result of selective neuronal loss in the hippocampus and surrounding areas of the cerebral ... -
Analysis of the modulatory effects of amyloid-beta and age on microglial activation
(Trinity College. Institute of Neuroscience, 2009)Microglia are the resident immune cells of the brain, and in the healthy brain they are believed to be responsible for the clearance of amyloid-beta (Aβ). Age is a primary risk factor for Alzheimer’s disease (AD) and the ... -
Sensory studies in adult-onset primary torsion dystonia
(Trinity College. Institute of Neuroscience, 2011)Dystonia is a disorder of movement characterized by prolonged muscle contractions, causing sustained twisting movements and abnormal postures of the affected body parts. Sensory symptoms including pain are frequently ... -
The heterogeneity of cognitive and behavioural impairment in Amyotrophic Lateral Sclerosis & its clinical implications
(Trinity College. Institute of Neuroscience, 2013)Amyotrophic Lateral Sclerosis (ALS) is the most common motor neuron disease in adults. The striking heterogeneity that characterizes ALS as disorder is one of the major challenges of research into ALS epidemiology, ... -
Noradrenergic control of inflammatory processes in the central nervous system
(Trinity College (Dublin, Ireland). Institute of Neuroscience, 2007)Evidence suggests tliat the monoannine neurotransmitter noradrenaline (NA) elicits anti-inflammatory actions in the central nervous system (CNS), and consequently may play an endogenous neuroprotective role in CNS disorders ... -
The development and validation of the EAMI as an assessment of episodic autobiographical recall
(Trinity College (Dublin, Ireland). Institute of Neuroscience, 2008)This thesis focuses on the development and validation of a new measure of episodic autobiographical memory, in line with current conceptual revisions to the concept of episodic memory (Tulving, 2002), which see episodic ... -
Mechanisms underlying stress-induced changes in the cytokine network : implications for cancer progression
(Trinity College (Dublin, Ireland). Institute of Neuroscience, 2008)Numerous studies have reported that exposure to psychological stress suppresses various aspects of the innate and adaptive immune responses, including impairment of the cytokine network. In agreement with these reports, ... -
The molecular, cellular and behavioural effects of electroconvulsive stimulation in the rodent brain
(Trinity College (Dublin, Ireland). Institute of Neuroscience, 2012)Electroconvulsive therapy (ECT) is the most effective treatment available for severe depression however its mechanisms of action have not been fully established. ECT administration is associated with memory deficits. To ...
