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dc.contributor.authorLAVELLE, EDWARD
dc.contributor.authorMARTIN, SEAMUS JOSEPH
dc.date.accessioned2014-11-25T14:56:12Z
dc.date.available2014-11-25T14:56:12Z
dc.date.issued2013
dc.date.submitted2013en
dc.identifier.citationCullen SP, Henry CM, Kearney CJ, Logue SE, Feoktistova M, Tynan GA, Lavelle EC, Leverkus M, Martin SJ, Fas/CD95-Induced Chemokines Can Serve as "Find-Me" Signals for Apoptotic Cells., Molecular cell, 49, 2013, 1 15en
dc.identifier.otherY
dc.identifier.urihttp://hdl.handle.net/2262/72186
dc.descriptionPUBLISHEDen
dc.description.abstractApoptosis is commonly thought to represent an immunologically silent or even anti-inflammatory mode of cell death, resulting in cell clearance in the absence of explicit activation of the immune system. However, here we show that Fas/CD95-induced apoptosis is associated with the production of an array of cytokines and chemokines, including IL-6, IL-8, CXCL1, MCP-1, and GMCSF. Fas-induced production of MCP-1 and IL-8 promoted chemotaxis of phagocytes toward apoptotic cells, suggesting that these factors serve as ``find-me?? signals in this context. We also show that RIPK1 and IAPs are required for optimal production of cytokines and chemokines in response to Fas receptor stimulation. Consequently, a synthetic IAP antagonist potently suppressed Fas-dependent expression of multiple proinflammatory mediators and inhibited Fas- induced chemotaxis. Thus, in addition to provoking apoptosis, Fas receptor stimulation can trigger the secretion of chemotactic factors and other immuno- logically active proteins that can influence immune responsiveness toward dying cellsen
dc.description.sponsorshipWe gratefully acknowledge Domagoj Vucic (Genentech, USA) for provision of BV6. We thank P. Schneider for a CD95L-Fc construct, and P.H. Krammer for antibodies C15 (caspase-8), NF-6 (cFLIP), and Apo-1 IgG3. The Martin laboratory is supported by PI (08/IN.1/B2031) and SRC (07/SRC/B1144) grants from Science Foundation Ireland. C.J.K. was supported by an IRCSET postgraduate studentship (RS/2010/2542). M.L.wassupportedbygrantsfrom the DFG (Le 953/6-1 and 8-1), the Wilhelm-Sander-Stiftung (2008.072.1), and the Mildred-Scheel-Stiftung (Projekt 109891). S.J.M. is a Science Foundation Ireland Principal Investigator.en
dc.format.extent1 15en
dc.language.isoenen
dc.relation.ispartofseriesMolecular cell;
dc.relation.ispartofseries49;
dc.rightsYen
dc.subjectApoptosisen
dc.subject.lcshApoptosisen
dc.titleFas/CD95-Induced Chemokines Can Serve as "Find-Me" Signals for Apoptotic Cells.en
dc.typeJournal Articleen
dc.type.supercollectionscholarly_publicationsen
dc.type.supercollectionrefereed_publicationsen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/lavellee
dc.identifier.peoplefinderurlhttp://people.tcd.ie/martinsj
dc.identifier.rssinternalid84022


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