Fas/CD95-Induced Chemokines Can Serve as "Find-Me" Signals for Apoptotic Cells.
Citation:
Cullen SP, Henry CM, Kearney CJ, Logue SE, Feoktistova M, Tynan GA, Lavelle EC, Leverkus M, Martin SJ, Fas/CD95-Induced Chemokines Can Serve as "Find-Me" Signals for Apoptotic Cells., Molecular cell, 49, 2013, 1 15Download Item:
Abstract:
Apoptosis is commonly thought to represent an
immunologically silent or even anti-inflammatory
mode of cell death, resulting in cell clearance in the
absence of explicit activation of the immune system.
However, here we show that Fas/CD95-induced
apoptosis is associated with the production of an
array of cytokines and chemokines, including IL-6,
IL-8, CXCL1, MCP-1, and GMCSF. Fas-induced
production of MCP-1 and IL-8 promoted chemotaxis
of phagocytes toward apoptotic cells, suggesting
that these factors serve as ``find-me?? signals in this
context. We also show that RIPK1 and IAPs are
required for optimal production of cytokines and
chemokines in response to Fas receptor stimulation.
Consequently, a synthetic IAP antagonist potently
suppressed Fas-dependent expression of multiple
proinflammatory mediators and inhibited Fas-
induced chemotaxis. Thus, in addition to provoking
apoptosis, Fas receptor stimulation can trigger the
secretion of chemotactic factors and other immuno-
logically active proteins that can influence immune
responsiveness toward dying cells
Author's Homepage:
http://people.tcd.ie/lavelleehttp://people.tcd.ie/martinsj
Description:
PUBLISHED
Author: LAVELLE, EDWARD; MARTIN, SEAMUS JOSEPH
Type of material:
Journal ArticleCollections
Series/Report no:
Molecular cell;49;
Availability:
Full text availableKeywords:
ApoptosisMetadata
Show full item recordLicences: