RSS 1.0Clinical Medicine
Collections in this Academic/Research Unit
-
Clinical Medicine (Live Theses)
Clinical Medicine (Live Theses) -
Clinical Medicine (Scholarly Publications)
Clinical Medicine (Scholarly Publications) -
Clinical Medicine (Theses and Dissertations)
Clinical Medicine (Theses and Dissertations)
Recent Submissions
-
Investigating the Epidemiology of Mycobacterium bovis Infection in Humans in Ireland.
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2024)Mycobacterium bovis is the main cause of bovine tuberculosis. It can cause zoonotic infection in humans. An average of 6 human M. bovis infections are notified annually in Ireland. Little is currently known about the ... -
Anal Cancer Prevention in HIV-Positive and HIV-Negative Men who have Sex with Men: (Exploring Screening tests of Another Disease State (Cervical Cancer) to Inform Future Screening Strategies for Anal Cancer and its Precursor Lesions among a High-Risk Population in Ireland.)
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2024)Introduction: Human Papillomavirus (HPV) is the commonest sexually transmitted infection (STI) in the world. “high-risk” (hr) HPV types are associated with causing or contributing to intraepithelial neoplasia and carcinoma ... -
Small-Bowel Capsule Endoscopy Optimising Capsule Endoscopy in Clinical Practice
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2024)This thesis evaluated three aspects of the clinical application of small bowel cap- sule endoscopy (SBCE). The first section looked at the use of the patency capsule in clinical practice and evaluated its limitations. ... -
A PROSPECTIVE ASSESSMENT OF COLON CAPSULE ENDOSCOPY AS A COLONIC POLYP SURVEILLANCE TECHNIQUE IN IRELAND, AND FUTURE DEVELOPMENTS
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2024)Colorectal cancer (CRC) has a significant global impact in terms morbidity and mortality. Our knowledge of its natural course, and its growth from a precursor lesion as a polyp, gives us the opportunity to prevent CRC ... -
Analysis of the Outcomes of Micro-Vascular Reconstruction following the Management Head and Neck Cancer
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2024) -
Investigation of oral problems using a novel oral symptom assessment tool in patients with advanced cancer and older patients with frailty.
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, School of Medicine, 2024)Oral symptoms are common in patients with advanced cancer. Certain oral symptoms like xerostomia are common in older patients. The prevalence of many oral symptoms is however unknown in older patients with frailty. Oral ... -
Cell landscape of immunosuppressive reprogramming during fatal sepsis and severe-COVID-19 through scRNA-SEQ
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2024)It is evident that some patients with sepsis and septic shock are admitted to hospitals late in their illness, contributing to poor outcomes and high mortality rates across all age groups worldwide. Current diagnostic and ... -
An Evaluation of In-Hospital Stroke in Irish Acute Hospitals
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2024)Introduction Between 1 and 17% of strokes occur in-hospital in patients hospitalised for another reason. In-hospital strokes are associated with worse outcomes and poor performance on quality-of-care measures of acute ... -
Biological Ageing: A study of telomere length and mitochondrial DNA copy number in anorexia nervosa
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2024)INTRODUCTION Patients with anorexia nervosa (AN) experience significant psychological and physical stress, which are risk factors for accelerated biological ageing. Telomeres are protective caps at the ends of chromosomes ... -
Analysis of genotype and phenotype in Leber Hereditary Optic Neuropathy-affected patients and asymptomatic maternal relatives
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2024)Analysis of genotype and phenotype in Leber Hereditary Optic Neuropathy-affected patients and asymptomatic maternal relatives MD in Clinical Medicine: Dr Clare Quigley Supervisor: Prof Lorraine Cassidy Introduction: Leber ... -
Biomarker discovery in non-small cell lung cancer
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2024)In Ireland, lung cancer represents the third most common cancer, after breast and prostate cancer. Major improvements have been made in treating this disease with the advent of targeted therapies and immunotherapy. These ... -
Characterising Macrophage Immunometabolism in Mycobacterium tuberculosis and HIV Co-Infection
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2024)Introduction Tuberculosis (TB) and HIV are leading infection-related causes of global mortality and result in an enormous amount of suffering and economic loss. Available TB treatment strategies are inadequate, and vaccination ... -
Investigation of the role of immunomodulators oftoll-like receptor 3 (TLR3) function and associated genetic variants in the pathogenesis and progression of idiopathic pulmonary fibrosis (IPF)
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2024)IPF is a fatal interstitial lung disease of unknown aetiology, with a lack of valid biomarkers and satisfactory therapeutic solutions available. Studies have shown an association between inflammation, viral and bacterial ... -
Genotypic and phenotypic insights into an Irish axial spondyloarthritis cohort
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2024)Axial spondyloarthritis (AxSpA) encompasses a group of closely related chronic inflammatory conditions which primarily affect the lumbar spine. The prototypic presentation of the disease is ankylosing spondylitis, which ... -
Investigating a role for SARM1 in retinal degeneration
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2024)Retinal degenerative diseases, such as retinitis pigmentosa (RP) and age-related macular degeneration (AMD), represent a leading cause of incurable blindness worldwide. RP is a genetically inherited retinal degeneration ... -
Profiling Serum and Tissue Biomarkers of Vedolizumab Therapy Response in Inflammatory Bowel Disease.
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2024)Introduction: Vedolizumab (VDZ) is a novel biologic agent proven effective for Inflammatory bowel disease (IBD), however, a significant proportion of patients do not respond to VZD treatment Aims: This thesis evaluates ... -
Exploring the effects of time-restricted eating as a novel intervention in patients with polycystic ovarian syndrome
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2024)Introduction: Polycystic ovarian syndrome (PCOS) is associated with hyperinsulinemia, insulin resistance and a high lifetime risk of developing type-2 diabetes mellitus. While many dietary interventions have been tested ... -
The Role of EUS and Proteomic Analysis in the Management and Surveillance of Pancreatic Cystic Lesions
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2024)Introduction Pancreatic cystic lesions (PCL) can be precursors to pancreatic cancer. The incidence of PCL are increasing worldwide with increased patient age and reliance on cross sectional imaging. However, not all PCL ... -
Network Analysis in Amyotrophic Lateral Sclerosis during Voluntary Motor Task: Neurophysiological Biomarkers of Disrupted Cortical Connections
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2024)Amyotrophic lateral sclerosis (ALS) is a fatal progressive neurodegenerative disease that causes degeneration of both upper and lower motor neurons primarily affecting the motor system, but individual people with ALS show ... -
Characterisation of a mutant mouse model of spontaneous atopic dermatitis
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2017)Atopy is Immunoglobulin-E sensitisation to “allergens” such as pollen and food. Atopic dermatitis is a pruritic eczematous dermatitis associated with an early onset in infants. Atopic dermatitis has a complex pathology and ...
