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dc.contributor.authorO'MARA, SHANEen
dc.date.accessioned2014-03-07T11:54:49Z
dc.date.available2014-03-07T11:54:49Z
dc.date.issued2013en
dc.date.submitted2013en
dc.identifier.citationMullally, SL & O'Mara, SM, Suppressing the encoding of new information: A behavioral study derived from principles of hippocampal function., PLoS One, 8, 1, 2013, e50814en
dc.identifier.otherYen
dc.identifier.urihttp://hdl.handle.net/2262/68230
dc.descriptionPUBLISHEDen
dc.description.abstractCognitive processes do not occur in isolation. Interactions between cognitive processes can be observed as a cost in performance following a switch between tasks, a cost that is greatest when the cognitive requirements of the sequential tasks compete. Interestingly, the long-term mnemonic goals associated with specific cognitive tasks can also directly compete. For example, encoding the sequential order in which stimuli are presented in the commonly-utilised 2-Back working memory (WM) tasks is counter-productive to task performance, as this task requires the continual updating of the contents of one?s current mental set. Performance of this task consistently results in reduced activity within the medial temporal lobe (MTL), and this response is believed to reflect the inhibitory mnemonic component of the task. Conversely, there are numerous cognitive paradigms in which participants are explicitly instructed to encode incoming information and performance of these tasks reliably increases MTL activity. Here, we explore the behavioural cost of sequentially performing two tasks with conflicting long-term mnemonic goals and contrasting neural profiles within the MTL. We hypothesised that performing the 2-Back WM prior to a hippocampal-dependent memory task would impair performance on the latter task. We found that participants who performed the 2-Back WM task, prior to the encoding of novel verbal/face-name stimuli, recollected significantly fewer of these stimuli, compared to those who had performed a 0-Back control task. Memory processes believed to be independent of the MTL were unaffected. Our results suggest that the inhibition of MTL- dependent mnemonic function persists beyond the cessation of the 2-Back WM task and can alter performance on entirely separate and subsequently performed memory tasks. Furthermore, they indicate that performance of such tasks may induce a temporarily-sustained, virtual lesion of the hippocampus, which could be used as a probe to explore cognitive processes in the absence of hippocampal involvementen
dc.format.extente50814en
dc.language.isoenen
dc.relation.ispartofseriesPLoS Oneen
dc.relation.ispartofseries8en
dc.relation.ispartofseries1en
dc.rightsYen
dc.subjectHippocampusen
dc.titleSuppressing the encoding of new information: A behavioral study derived from principles of hippocampal function.en
dc.typeJournal Articleen
dc.type.supercollectionscholarly_publicationsen
dc.type.supercollectionrefereed_publicationsen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/smomaraen
dc.identifier.rssinternalid92350en
dc.identifier.doihttp://dx.doi.org/journal.pone.0050814en
dc.rights.ecaccessrightsOpenAccess
dc.subject.TCDThemeNeuroscienceen
dc.subject.TCDTagBehavioral/Experimental Psychologyen


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