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dc.contributor.authorBOWIE, ANDREWen
dc.date.accessioned2014-02-18T09:26:05Z
dc.date.available2014-02-18T09:26:05Z
dc.date.issued2011en
dc.date.submitted2011en
dc.identifier.citationPaludan, S.R., Bowie, A.G., Horan, K.A., Fitzgerald, K.A., Recognition of herpesviruses by the innate immune system, Nature Reviews Immunology, 11, 2011, 143 - 154en
dc.identifier.otherYen
dc.identifier.urihttp://hdl.handle.net/2262/68078
dc.descriptionPUBLISHEDen
dc.descriptionPubMed ID: 21267015en
dc.description.abstractAdvances in innate immunity over the past decade have revealed distinct classes of pattern recognition receptors (PRRs) that detect pathogens at the cell surface and in intracellular compartments. This has shed light on how herpesviruses, which are large disease-causing DNA viruses that replicate in the nucleus, are initially recognized during cellular infection. Surprisingly, this involves multiple PRRs both on the cell surface and within endosomes and the cytosol. In this article we describe recent advances in our understanding of innate detection of herpesviruses, how this innate detection translates into anti-herpesvirus host defence, and how the viruses seek to evade this innate detection to establish persistent infections.en
dc.description.sponsorshipThis work was supported by grants from The Danish Medical Research Council (09--?072636), The Lundbeck Foundation (R34--?A3855), Velux Fonden, Kathrine og Vigo Skovgaards Fond, and Elvira og Rasmus Riisforts almenvelg?rende Fond (awarded to SRP), by grants from the NIH (AI067497, AI64349, AI083713 and AI079293) awarded to KAF and by grants from Science Foundation Ireland to AGB. KAH was supported by a Marie Curie Incoming International Fellowship.en
dc.format.extent143en
dc.format.extent154en
dc.language.isoenen
dc.relation.ispartofseriesNature Reviews Immunologyen
dc.relation.ispartofseries11en
dc.rightsYen
dc.subjectHerpesen
dc.titleRecognition of herpesviruses by the innate immune systemen
dc.typeJournal Articleen
dc.type.supercollectionscholarly_publicationsen
dc.type.supercollectionrefereed_publicationsen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/agbowieen
dc.identifier.rssinternalid75174en
dc.identifier.doihttp://dx.doi.org/10.1038/nri2937en
dc.rights.ecaccessrightsOpenAccess
dc.subject.TCDThemeImmunology, Inflammation & Infectionen
dc.contributor.sponsorScience Foundation Ireland (SFI)en


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