Synthesis, spectroscopic and biological studies of a fluorescent Pt(ii) (terpy) based 1,8-naphthalimide conjugate as a DNA targeting agent.

KELLY, JOHN MOFFAT; WILLIAMS, DAVID CLIVE; GUNNLAUGSSON, THORFINNUR

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Journal Article

Date:

2013

Author:

KELLY, JOHN MOFFAT

WILLIAMS, DAVID CLIVE

GUNNLAUGSSON, THORFINNUR

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OpenAccess

Citation:

Banerjee S, Kitchen JA, Bright SA, O'Brien JE, Williams DC, Kelly JM, Gunnlaugsson T, Synthesis, spectroscopic and biological studies of a fluorescent Pt(ii) (terpy) based 1,8-naphthalimide conjugate as a DNA targeting agent., Chemical communications (Cambridge, England), 49, 76, 2013, 8522-8524

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Abstract:

The bi-functional complex [PtII(terpy)(py-naphth)](NO 3)2(1), incorporating both 2,2?:6?, 2??-terpyridine and 4-N,N?-dimethylamino-1,8-naphthalimide moieties, displays a high binding affinity for DNA as well as displaying cytotoxicity towards and inducing apoptosis in malignant cell lines.