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dc.contributor.authorFARES, MARIO ALI
dc.date.accessioned2013-09-02T11:36:06Z
dc.date.available2013-09-02T11:36:06Z
dc.date.issued2012
dc.date.submitted2012en
dc.identifier.citationAlvarez-Ponce, D., Fares, M.A., Evolutionary rate and duplicability in the Arabidopsis thaliana protein-protein interaction network, Genome Biology and Evolution, 4, 12, 2012, 1263-1274en
dc.identifier.otherY
dc.identifier.urihttp://hdl.handle.net/2262/67296
dc.descriptionPUBLISHEDen
dc.description.abstractGenes show a bewildering variation in their patterns of molecular ev olution, as a result of the action of different levels and types of selective forces. The factors underlying this variation are, however, s till poorly understood. In the last decade, the position of proteins in the protein?protein interaction network has been put forward as a determinant factor of the evolutionary rate and duplicability of their encoding genes. This conclusion, however, has been based on the analysis of the limited number of microbes and animals for which interactome-level data are available (essentially, Escherichia coli , yeast, worm, fly, and humans). Here, we study, for the first time, the relationship between the position of pro teins in the high-density interactome of a plant ( Arabidopsis thaliana )andthe patterns of molecular evolution of their encoding genes. We found that genes whose encoded products act at the center of the network are more evolutionarily constrained than those acting a t the network periphery. This trend remains significant when potential confounding factors (gene expression level and breadth, duplicability, function, and length of the encoded products) are controlled for. Even though the correlation between centrality measures and rates of evolution is generally weak, for some functional categories, it is comparable in strength to (or even stronger than) the correlation between evolutionary rates and expression levels or breadths. In addition, genes encoding interacting proteins i n the network evolve at relatively similar rates. Finally, Arabidopsis proteins encoded by duplicated genes are more highly connected than those encoded by singleton genes. This observation is in agreement with the patterns observed in humans, but in contrast with those observed in E. coli , yeast, worm, and fly (whose duplicated genes tend to act at the periphery of the network), implying that the rela tionship between duplicability and centrality inverted at least twice during eukaryote evolution. Taken together, these results indicate that the structure of the A. thaliana network constrains the evolution of its components at multiple levelsen
dc.description.sponsorshipThis study was supported by a grant from the Spanish Ministerio de Ciencia e Innovacio ? n (BFU2009-12022) and a grant from the Research Frontiers Program (10/RFP/ GEN2685) from Science Foundation Ireland to MAF. D.A.-P. was supported by a Juan de la Cierva postdoctoral fellowship from the Spanish Ministerio de Econom? ? a y Competitividad (JCI-2011-11089). We are grateful to two anonymous ref- erees for their helpful commentsen
dc.format.extent1263-1274en
dc.language.isoenen
dc.relation.ispartofseriesGenome Biology and Evolution;
dc.relation.ispartofseries4;
dc.relation.ispartofseries12;
dc.rightsYen
dc.subjectnetwork evolution, Arabidopsis interactome, natural selection, rates of evolution, gene duplication, network centralityen
dc.subject.lcshnetwork evolution, Arabidopsis interactome, natural selection, rates of evolution, gene duplication, network centralityen
dc.titleEvolutionary rate and duplicability in the Arabidopsis thaliana protein-protein interaction networken
dc.typeJournal Articleen
dc.type.supercollectionscholarly_publicationsen
dc.type.supercollectionrefereed_publicationsen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/faresm
dc.identifier.rssinternalid86521


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