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dc.contributor.authorMc Manus, Rossen
dc.date.accessioned2013-08-07T13:37:53Z
dc.date.available2013-08-07T13:37:53Z
dc.date.issued2011en
dc.date.submitted2011en
dc.identifier.citationMahabeleshwar GH, Kawanami D, Sharma N, Takami Y, Zhou G, Shi H, Nayak L, Jeyaraj D, Grealy G, White M, McManus R, Ryan T, Leahy P, Lin Z, Haldar SM, Atkins GB, Wong HR, Lingrel JB, Jain MK, Myeloid KLF2 Regulates the Host Response to Polymicrobial Infection and Endotoxic Shock, Immunity, 34, 2011, 715 - 728en
dc.identifier.otherYen
dc.identifier.urihttp://hdl.handle.net/2262/66894
dc.descriptionPUBLISHEDen
dc.description.abstractPrecise control of myeloid cell activation is required for optimal host defense. However, this activation process must be under exquisite control to prevent uncontrolled inflammation. Herein, we identify the Kruppel-like transcription factor 2 (KLF2) as a potent regulator of myeloid cell activation in vivo. Exposure of myeloid cells to hypoxia and/or bacterial products reduced KLF2 expression while inducing hypoxia indusable factor-1 ? (HIF-1 ? ), findings that were recapitulated in human septic patients. Myeloid KLF2 was found to be a potent inhibitor of nuclear factor- kappaB (NF ? B)-dependent HIF-1 ? transcription and, consequently, a critical determinant of outcome in models of polymicrobial infection and endotoxemia. Collectively, these observations identify KLF2 as a tonic repressor of myeloid cell activation in vivo and an essential regulator of the innate immune systemen
dc.description.sponsorshipThis work was supported, in whole or in part, by National Institutes of Health Grants HL72952, HL75427, HL76754, HL086548, HL084154, and P01 HL048743 (M. K. J.); HL097023 (G.H.M) HL 78806 (J. L.); HL087595 (Z. L.); HL088740 (G. B. A.); HL086614 (S.M.H); HL094660 (D.J); GM064619 and HL100474 (H.R.W.); a Robert Wood Johnson/Harold Amos Medical Faculty Development grant (G. B. A.), a Dominic Visconsi Scholar Award (S.M.H, G.B.A.), American Heart Association Grants 0725297B (D.K); 09POST2060203 (N.S.), Sankyo Foundation of Life Science grants (Y.T.), and a Kanae Foundation for the Promotion of Medical Science grant (Y.T. and D. K.). The authors declare no competing conflict-of financial interests.en
dc.format.extent715en
dc.format.extent728en
dc.language.isoenen
dc.relation.ispartofseriesImmunityen
dc.relation.ispartofseries34en
dc.rightsYen
dc.subjectMyeloid KLF2en
dc.subject.lcshMyeloid KLF2en
dc.titleMyeloid KLF2 Regulates the Host Response to Polymicrobial Infection and Endotoxic Shocken
dc.typeJournal Articleen
dc.type.supercollectionscholarly_publicationsen
dc.type.supercollectionrefereed_publicationsen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/rmcmanusen
dc.identifier.rssinternalid77040en
dc.identifier.doihttp://dx.doi.org/10.1016/j.immuni.2011.04.014en
dc.subject.TCDThemeGenes & Societyen
dc.subject.TCDThemeImmunology, Inflammation & Infectionen
dc.subject.TCDThemeInternational Developmenten


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