RSS 1.0Biochemistry
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Biochemistry (Theses and Dissertations)
Recent Submissions
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Characterisation of the T cell response during Staphylococcus aureus nasal colonisation
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2025)While Staphylococcus aureus is primarily recognised as an invasive pathogen, it is also an important component of the normal human microbiome, persistently colonising the nasal tissue (NT) of a significant proportion of ... -
Investigation into the Molecular Mechanisms Underlying Cisplatin Resistance in Oral Squamous Cell Carcinoma
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2025)Oral Squamous Cell Carcinoma (OSCC) is the 6th most common cancer worldwide. It is generally aggressive and closely associated with chemoresistance and poor survival. Cisplatin serves as one of the mainstay drugs in the ... -
Rational drug design and biochemical analysis in the development of targeted therapies against Malignant Pleural Mesothelioma
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2012)Malignant Pleural Mesothelioma (MPM) is a fatal neoplasm arising from cells of the esothelial lining of the pleural cavity and associated with prolonged exposure to asbestos. This highly resistant malignancy is largely ... -
Beyond Glucose Control: The Impact of Metformin on the Appetite-Suppressing Metabolite Lac-Phe and Fatty Acid Metabolism in Humans
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2025)Metformin, a widely used first-line treatment for type 2 diabetes (T2D), is known to reduce blood glucose levels, suppress appetite, and exert anti-inflammatory effects. However, despite extensive research on its clinical ... -
PLGA particle size as a critical modulator of immune tolerance via ⍺vβ3 mechano-sensor engagement
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2025)The increasing prevalence of inflammatory and autoimmune conditions underscores the critical need for novel therapeutic strategies that modulate inflammation without impairing the capacity to mediate protective immunity ... -
4-octyl itaconate and itaconate in the regulation of type I interferon in macrophages
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2025)Itaconate is an endogenous immunomodulatory metabolite produced by the enzyme aconitate decarboxylase 1 (ACOD1), a product of the gene immune-responsive gene 1 (Irg1). Itaconate is the most highly upregulated metabolite ... -
The induction of trained immunity through dietary supplementation with b-glucan boosts myeloid anti-tumour immunity in diet induced obesity
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2025)Over the last 10 years, emerging concepts in our understanding of immunological memory have broadened the field to recognise that immunological memory is not a feature that is unique to the mammalian adaptive immune system. ... -
Rational design of particulate vaccine adjuvants for enhanced T cell-mediated immunity
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2025)Resolving the mechanisms underlying the immunostimulatory properties of vaccine adjuvants is critical to provide a basis for rational adjuvanted vaccine design for specific diseases and target groups. Building on this, ... -
Mycobacterium tuberculosis attenuates Macrophage responses through Pentose Phosphate Pathway activity
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2025)Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis, is adept at evading host immune defences and establishing chronic infections, particularly within macrophages. Central to its survival is its ability ... -
Plasticity of instinct: Interactions of the memory engram with innate behaviour
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2025)The brain has access to two sources of information to guide behaviour; instinct and memory. While research into these two phenomena is advancing rapidly, much less is known about how they interact with one another. This ... -
Investigating the Mechanisms of Memory Engram Plasticity in Infantile Amnesia
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2025)Infantile amnesia describes the inability to recall memories formed during a critical period of development in infancy and early childhood. While significant advancements have been made in characterizing this phenomenon ... -
Pathogen-derived immunomodulatory molecules: future immunotherapeutics?
(2007-10-17)The identification of molecules from various pathogens that modulate innate and/or adaptive immunity is a dynamic and rapidly developing area of research. These immunomodulatory molecules (IM) have been optimized during ... -
Vaccine-induced tissue-resident memory T cells and mucosal immunity to respiratory pathogens
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2025)Respiratory infections cause considerable morbidity and mortality globally, in particular in the most vulnerable individuals in our societies. Whooping cough (pertussis) is a respiratory disease caused by the Gram-negative ... -
Metabolic characterisation and modulation of the immune response to biomaterials for bone tissue engineering
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2025)The limited capacity of many tissues and organs to adequately repair and regenerate lies at the heart of numerous healthcare challenges. Difficulties faced in promotion of tissue healing and regrowth have begun to be tackled ... -
The role of natural killer cells in the immune response to hepatitis C virus
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2016)Hepatitis C virus (HCV) infection remains a major clinical problem, particularly in the developing world where high cost makes treatment inaccessible to many. Those coinfected with HIV also face poorer prognosis and increased ... -
TLR2-dependent type 1 interferon induction in human monocytes and its relevance to Staphylococcus aureus infection
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2016)Even though Staphylococcus aureus is a part of healthy microflora, it is also a significant human pathogen causing mild as well as life-threatening infections. Furthermore, an increasing incidence of antibiotic resistant ... -
The role of IL-17A in central nervous system autoimmunity
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2017)Multiple sclerosis (MS) is a chronic demyelinating inflammatory disorder of the central nervous system (CNS), involving autoreactive T cell responses to myelin antigens. Experimental autoimmune encephalomyelitis (EAE) is ... -
Studies on the CNS effects of systemic inflammation induced by dsRNA
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2016)Poly-Inosinic: Poly-Cytidylic Acid (poly I:C) is a synthetic double stranded analogue that contains the main components of a double stranded ribonucleic acid (dsRNA). It is often used in neuroimmunology to mimic the effects ... -
Innate immune regulation of secretory IgA responses
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2016)Owing to its unique biological function, the gastrointestinal tract (GIT) is constitutively exposed to a plethora of antigens including those of dietary and environmental origin. In addition, the enormous bacterial burden ... -
Innate DNA sensing mechanisms and PYHIN protein function in epithelial cell lines
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2016)In the last decade mechanisms for innate immune sensing of pathogens and self nucleic acids have been defined. For cytosolic sensing of DNA, the adaptor protein STING has a central role, operating downstream of DNA sensors ...
