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dc.contributor.authorTIPTON, KEITH
dc.date.accessioned2011-04-18T11:48:47Z
dc.date.available2011-04-18T11:48:47Z
dc.date.issued2011
dc.date.submitted2011en
dc.identifier.citationRoberta J Ward, Frederic Lallemand, Philippe de Witte, Robert R Crichton, Jacques Piette, Keith Tipton, Karl Hemmings, Arnaud Pitard, Mike Page, Laura Della Corte, Deanna Taylor, David Dexter, Anti-inflammatory actions of a taurine analogue; ethane ?-sultam; in phagocytic cells; in vivo and in vitro, Biochemical Pharmacology, 81, 2011, 743 - 751en
dc.identifier.otherY
dc.identifier.urihttp://hdl.handle.net/2262/54884
dc.descriptionPUBLISHEDen
dc.description.abstractThe ability of a taurine prodrug, ethane ?-sultam, to reduce cellular inflammation has been investigated, in vitro, in primary cultures of alveolar macrophages and an immortilised N9 microglial cell line and in vivo in an animal model of inflammation and control rats. Ethane ?-sultam showed enhanced ability to reduce the inflammatory response in alveolar macrophages, as assayed by the lipopolysaccharide-stimulated?nitric oxide release, (LPS stimulated-NO), in comparison to taurine both in vitro (10 nM, 50 nM) and in vivo (0.15mmol/kg/day by gavage). In addition, ethane ?-sultam, (50, 100 and 1000 nM) significantly reduced LPS-stimulated glutamate release from N9 microglial cells to a greater extent than taurine. The anti-inflammatory response of taurine was shown to be mediated via stabilisation of IkB?. The use of a taurine prodrug as therapeutic agents, for the treatment of neurological conditions, such as Parkinson's and Alzheimer's disease and alcoholic brain damage, where activated phagocytic cells contribute to the pathogenesis, may be of great potential.en
dc.format.extent743en
dc.format.extent751en
dc.language.isoenen
dc.publisherElsevieren
dc.relation.ispartofseriesBiochemical Pharmacology;
dc.relation.ispartofseries81;
dc.rightsYen
dc.subjectPharmacology and pharmacyen
dc.subjecttaurineen
dc.subjectanti-inflammatoryen
dc.titleAnti-inflammatory actions of a taurine analogue; ethane ?-sultam; in phagocytic cells; in vivo and in vitroen
dc.typeJournal Articleen
dc.type.supercollectionscholarly_publicationsen
dc.type.supercollectionrefereed_publicationsen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/ktipton
dc.identifier.rssinternalid70355
dc.identifier.rssurihttp://dx.doi.org/10.1016/j.bcp.2010.12.030en


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